大动脉根尺寸与急性心力衰竭死亡率的相关性:全国范围的前性队列研究
Zeming Zhou1, Wei Wang1,2, Lili Tian3
1National Clinical Research Center for Cardiovascular Diseases, NHC Key Laboratory of Clinical Research for Cardiovascular Medications, Fuwai Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, National Center for Cardiovascular Diseases, Beijing, China.
Heliyon
|September 19, 2024
概括
与体重指数 (BMI) 索引的下大动脉根尺寸 (ARD) 与急性心力衰竭 (AHF) 患者的死亡率降低有关. 在这种关联中,也观察到性别特异性差异.
科学领域:
- 心脏病学 心脏病学
- 心血管研究研究心血管研究
- 心脏衰竭管理的管理
背景情况:
- 大动脉根尺寸 (ARD) 的增加与一般人群中较高的心血管死亡率有关.
- 有限证据表明ARD与死亡率之间的关联,特别是在急性心力衰竭 (AHF) 患者中.
研究的目的:
- 调查身体质量指数 (BMI) 索引的ARD与AHF患者的死亡率之间的关联.
- 探索BMI指数的ARD与死亡率之间的关系中的潜在性别特异性差异.
主要方法:
- 一项全国范围的前性队列研究 (中国以患者为中心的心脏事件评估前性心力衰竭研究) 包括2125名AHF患者.
- 大动脉根尺寸 (ARD) 通过心声学测量,并根据BMI进行索引.
- 考克斯的比例危险模型和受限制的立方线被用来分析BMI指数的ARD和死亡率之间的关联,考虑到竞争的风险和性别差异.
主要成果:
- 较低的BMI指数的ARD与较高的BMI指数的ARD相比,与心血管和全因死亡率的降低有显著关联.
- 根据BMI指数的ARD的最低三位数显示,所有人群和两性中心血管死亡风险较低.
- 在男性中观察到BMI指数的ARD和死亡率之间的线性关系,而在女性中发现了"J"形关系.
结论:
- 较低的BMI指数的ARD与AHF患者的死亡风险降低有关.
- 在BMI指数的ARD与死亡率之间的关系中存在显著的基于性别的差异.
- 这些发现有助于确定AHF患者的潜在死亡风险.
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