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中性细胞外细胞陷基因预测胃癌的免疫治疗反应

Ningjie Sun¹, Junjie Jiang², Biying Chen³

¹Department of Gastrointestinal Surgery, Yiwu Central Hospital, Yiwu, China.

|September 19, 2024

概括

中性细胞外细胞陷 (NETs) 与胃癌的进展和免疫疗法反应有关. 一个与NET相关的新型签名准确地预测了患者的结果和胃癌免疫治疗的反应.

科学领域:

在瘤学瘤学.
免疫学免疫学免疫学
分子生物学分子生物学

背景情况:

中性粒细胞外细胞陷 (NETs) 在宿主防御,癌症发育和免疫系统功能障碍中发挥作用.
在胃癌 (GC) 瘤微环境 (TME) 中,NETs的具体参与尚未得到充分理解.
鉴定NET相关基因表达的特征对于理解GC病变发生和治疗反应至关重要.

研究的目的:

为了研究胃癌中NET相关基因的表达模式.
分析NET相关基因与临床病理特征,预后,TME特征和GC免疫治疗疗效之间的关联.
开发基于NET相关基因签名的免疫治疗反应预测模型.

主要方法:

来自多个GC队列的转录组和单细胞RNA测序数据的分析 (TCGA-STAD,GSE62254,GSE15459,GSE183904).
利用共识聚类来定义NET相关的分子亚型.
在免疫疗法队列中使用LASSO回归,ROC和卡普兰-梅尔分析构建和验证了一种NET相关的基因特征.

主要成果:

在GC中确定了两个不同的NET相关集群,具有不同的临床病理特征和预后.
与高NET相关的集群显示出更具攻击性的瘤行为,更糟糕的预后,并丰富了TME免疫透和效应器功能.
开发的NET相关签名在预测免疫治疗反应 (AUC=0.939) 和治疗患者的良好预后方面表现出高准确性.

结论:

与NET相关的签名作为可靠的生物标志物,用于预测胃癌中免疫疗法的疗效.
这种签名可以帮助临床医生为GC患者选择适当的免疫疗法策略.
了解NET在GC TME中的作用为癌症进展和治疗提供了新的见解.

关键词:

胃癌胃癌是指胃癌.免疫治疗是一种免疫疗法.中性细胞细胞外陷响应响应响应响应

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