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长期 Δ9 - 四大麻治疗对mTOR活动和代谢的双向影响

Andras Bilkei-Gorzo¹, Britta Schurmann¹, Marion Schneider²

¹Institute of Molecular Psychiatry, Medical Faculty, University of Bonn, Bonn 53125, Germany.

ACS pharmacology & translational science

|September 19, 2024

概括

长期服用低剂量的 Δ9 - - 四大麻素 (THC) 通过促进突触功能和认知,有利于衰老的大脑. 这通过对拉巴胺素 (mTOR) 信号传递和新陈代谢的机械点的双重作用而发生,增强大脑能量和蛋白质合成.

科学领域:

神经科学是一个神经科学.
代谢学代谢学代谢学
药理学药理学是指药理学的学科.

背景情况:

大脑衰老导致认知能力下降,突触可塑性降低,以及代谢变化.
拉巴胺素 (mTOR) 信号传递的机械标对衰老和新陈代谢产生影响.
虽然减少的mTOR信号具有抗衰老作用,但它可能会损害老化大脑中的认知功能和突触生成.

研究的目的:

为了研究 Δ9 - 四大麻素 (THC) 对老化大脑中的 mTOR 信号传递和代谢的作用.
确定THC对认知功能和突触密度的积极影响是否与mTOR活动和代谢的变化有关.

主要方法:

在老老鼠中长期使用低剂量的Δ9THC.
对大脑,脂肪组织和血中的mTOR信号通路的分析.
脑组织和血的代谢分析.

主要成果:

-THC治疗诱导了脑mTOR活动,氨基酸和能量代谢物的短暂增加,随后是增强的突触蛋白质合成.
意想不到的是,THC降低了mTOR活性,改变了脂肪组织和血中的氨基酸和碳水化合物代谢,模仿了卡路里限制的影响.
这些发现揭示了THC对mTOR信号传递和代谢过程的双重影响.

结论:

长期使用低剂量的THC具有双重作用:促进大脑能量和突触功能,同时诱导周围代谢变化.
这种对mTOR信号传递和代谢组的双重影响可能是THC的益智和抗衰老益处的基础.
-THC具有作为治疗年龄相关认知衰退和大脑衰老的治疗剂的潜力.

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