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基于深入的网络药理学和分子对接的基础上,奎尔丁在改善反复性自发流产的新分子机制

Dan Wang¹, Xuebing Li², Yifan Li¹

¹The Second Clinical Medical College of Henan University of Chinese Medicine, Zhengzhou, China.

Frontiers in chemistry

|September 19, 2024

概括

奎尔可能有助于通过调节炎症和亡来减少复发性自发性流产 (RSA). 这项研究阐明了奎尔丁的含量.

科学领域:

药理学和毒理学药理学和毒理学
生殖生物学生殖生物学
分子生物学分子生物学

背景情况:

经常性自发流产 (RSA) 带来了重大挑战.
奎尔塞是一种黄类化合物,可能会降低流产率,但其机制尚不清楚.

研究的目的:

通过网络药理学,分子对接和实验验证,调查素缓解RSA的分子途径.

主要方法:

鉴定了素和RSA标基因,进行了途径丰富分析 (GO,KEGG) 和分子对接.
通过细胞检测和分子分析 (RT-qPCR,Western Blot) 在脂聚糖 (LPS) 诱导的HTR-8/SVneo细胞中得到验证的发现.

主要成果:

确定了25个重叠的目标基因,在细胞灭绝和免疫信号通路中进行了丰富.
奎尔提升了细胞增殖,迁移和入侵,同时降低了LPS诱导细胞的亡.
奎尔赛丁调节炎性细胞因子 (IL-1β,TNF-α,IL-6) 和关键蛋白质 (AKT1,MMP9,caspase-3).

结论:

Quercetin 通过 AKT1,MMP9 和 caspase-3 途径调节炎症和亡过程来缓解 RSA.
奎尔西为治疗复发性自发性流产提供了一种新的治疗方法.

关键词:

在HTR-8/SVneo细胞中.分子对接的分子对接.网络药理学网络药理学文素 (Quercetin) 是一种文素.经常发生的自发性流产.

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