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饮食中的欧米茄-3脂肪酸对减缓表型衰老加速的剂量反应关系:一个横截面研究

Dongzhe Wu¹, Yishuai Jia², Yujia Liu³

¹Department of Exercise Physiology, Beijing Sport University, Beijing, China.

Frontiers in nutrition

|September 19, 2024

概括

增加饮食中的Omega-3脂肪酸摄入量与更慢的加速表型衰老 (PhenoAgeAccel) 有关. 这表明,欧米茄-3脂肪酸可能是促进健康长寿和延缓衰老过程的关键饮食策略.

科学领域:

营养科学营养科学
老年学是一门学科.
生物化学生物化学

背景情况:

加快的表型衰老 (PhenoAgeAccel) 是生物衰老相对于时间年龄的衡量标准.
饮食因素,如欧米茄-3脂肪酸,越来越多地被认为对衰老过程的潜在影响.
了解营养摄入量与生物衰老之间的关系对于公共卫生战略至关重要.

研究的目的:

调查饮食中的欧米茄-3脂肪酸摄入量与PhenoAgeAccel之间的关联.
为了确定欧米茄-3的摄入是否可以减缓生物衰老.
探索欧米茄-3脂肪酸对衰老的公共卫生影响.

主要方法:

从NHANES (1999-2018) 中对20,337名成年人的横截面分析.
使用血液生物化学标记物计算PhenoAgeAccel的计算.
权重通用线性回归和限制立方线分析,以评估线性和非线性关系,包括值效应.

主要成果:

在Omega-3摄入量和PhenoAgeAccel (β = -0.071,p = 0.004) 之间观察到显著的负相关性.
每个单位增加的欧米茄-3摄入量与0.071单位的PhenoAgeAccel减少有关.
确定了一个值效应,益处稳定超过1.103克/天的欧米茄-3摄入量.

结论:

饮食中的欧米茄-3脂肪酸显示出调节PhenoAgeAccel的潜力.
增加欧米茄-3的摄入量可能是一个可行的饮食干预措施来减缓衰老.
研究结果支持个性化的营养策略,以优化不同人群的健康寿命.

关键词:

欧米茄-3 脂肪酸-3 脂肪酸衰老的衰老衰老的衰老营养健康营养健康现型年龄现型年龄现型年龄加速的表型

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