纤维细胞生长因子19在预测患有败血症的患者胃肠功能障碍的临床价值
Linsai Guan1, Feiyao Wang2, Jingni Chen3
1Department of Nursing, Shanghai Taikang Shenyuan Rehabilitation Hospital, Shanghai, China.
Frontiers in nutrition
|September 19, 2024
概括
纤维细胞生长因子19 (FGF19) 水平在患有胃肠道 (GI) 功能障碍的败血症患者中显著更高. FGF19显示为预测败血症中胃肠道功能障碍的新型生物标志物.
科学领域:
- 生物化学 生物化学
- 关键护理医学 关键护理医学
- 胃肠病学 胃肠病学
背景情况:
- 败血症可能导致胃肠道 (GI) 功能障碍,增加患者的死亡率.
- 确定肠道功能障碍在败血症中的可靠生物标志物对于及时干预至关重要.
研究的目的:
- 评估纤维细胞生长因子19 (FGF19) 作为毒症患者肠道功能障碍的潜在预测因子.
主要方法:
- 一项前性研究招募了209名在ICU的败血症患者.
- 在ICU入院时测量了血清FGF19水平.
- 进行了统计分析,包括曼-惠特尼U测试,斯皮尔曼相关性和ROC分析.
主要成果:
- 患有败血症相关的肠胃功能障碍的患者与没有败血症的患者相比,血清FGF19水平显著更高.
- FGF19表现出对肠道功能障碍的良好预测能力 (AUC = 0.773),表现优于前素 (PCT).
- 在胃肠道功能障碍患者中观察到更高的ICU死亡率.
结论:
- 血清FGF19可能作为一种新的预测或生物标志物用于消化道功能障碍在败血症.
- 需要进一步的研究来探索FGF19在败血症管理中的临床实用性.
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