牛皮的地理模式:对CorEvitas牛皮登记册的观察研究
Clinton W Enos1, Katie A O'Connell1, Ryan W Harrison2
1Department of Dermatology, Eastern Virginia Medical School, Norfolk, VA, USA.
Journal of psoriasis and psoriatic arthritis
|September 19, 2024
概括
牛皮病的严重程度和治疗结果因美国的不同地区而异. 东南中部地区的疾病严重程度较高,治疗成功率较低,这凸显了对患者护理的区域意识的需要.
科学领域:
- 皮肤病学 皮肤病学
- 公共卫生 公共卫生
- 流行病学 流行病学
背景情况:
- 美国各地的牛皮病特征,管理和结果的区域差异仍然不太了解.
- 了解这些地理差异对于优化患者护理和资源配置至关重要.
研究的目的:
- 评估CorEvitas牛皮病登记册中患者之间的牛皮病特征的区域差异.
- 随着时间的推移,报告生物启动课程的趋势.
- 为了评估区域治疗结果在6个月后续对新的生物启动.
主要方法:
- 在CorEvitas牛皮病登记 (2014-2019) 中,分析了来自6320名患者的7520个新的生物启动.
- 将患者分为7个美国地理区域进行分类,以进行比较分析.
- 描述基线人口统计,疾病特征和治疗结果 (PASI75,IGA 0/1) 在6个月.
主要成果:
- 在大多数地区,IL-17抑制剂是最常见的生物类别,其次是IL-12/23,IL-23和TNF抑制剂.
- 东南中部地区表现出最严重的牛皮的比例 (25.1%由BSA) 和代谢性并发病的最大患病率.
- 东南中部地区实现PASI75 (P = .008) 和IGA 0/1 (P = .001) 的比率较低,在6个月后生物断药率较高 (28.2%).
结论:
- 在美国,牛皮病的严重程度,并发症负担和治疗反应存在显著的区域差异.
- 东南中部地区面临着独特的挑战,疾病严重程度更高,治疗结果更差.
- 医疗保健提供者应该考虑这些区域趋势,以量身定制牛皮管理策略,并在全国范围内改善患者护理.
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