在骨质疏松和骨矿物质密度FGF21过度表达的影响:一个两个样本,调解门德尔分析
Jingjing Liu1, Jun Jiang1, Yunjia Li1
1Department of Spinal Surgery, Southern Central Hospital of Yunnan Province, Honghe, China.
Frontiers in endocrinology
|September 19, 2024
概括
纤维细胞生长因子21 (FGF21) 过度表达与较低的骨矿物质密度和骨质疏松症风险增加有关. 这些影响可能由2型糖尿病和基本代谢率介导.
科学领域:
- 代谢调节和骨健康问题
- 遗传流行病学遗传流行病学
- 内分泌学 在内分泌学.
背景情况:
- 纤维细胞生长因子21 (FGF21) 调节新陈代谢.
- 观察性研究表明,FGF21,骨矿物质密度和骨质疏松症之间存在联系.
- 这种因果关系仍然不清楚.
研究的目的:
- 调查FGF21与骨矿物密度 (BMD) 和骨质疏松症之间的因果关系.
- 探索FGF21-骨质疏松路径中的潜在调解因素.
主要方法:
- 两个样本,介导的孟德尔随机化 (MR) 分析.
- 利用全基因组关联研究 (GWAS) 的FGF21和各种BMD测量 (全身,脚跟,前臂,大腿) 和骨质疏松症的数据.
- 采用逆方差权衡 (IVW) 作为主要分析,补充加权中位数和MR-Egger回归,并进行灵敏度分析.
主要成果:
- 过度表达FGF21与所有测量部位的骨质量降低有关 (例如,全身OR=0.920,P=0.001).
- 过度表达FGF21显著增加了骨质疏松症的风险 (OR=1.003,P=0.004).
- 鉴定出2型糖尿病 (14.96%介导) 和基底代谢率 (12.21%介导) 是潜在的介导因素.
结论:
- 过度表达FGF21可能会导致骨矿物质密度下降并增加骨质疏松症的风险.
- FGF21对骨质疏松症的影响可能由2型糖尿病和基本代谢率介导.
- 研究结果提供了关于骨质疏松症机制和潜在治疗点的见解.
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