在怀孕期间母亲感染后,SARS-CoV-2在胎盘中复制
Anda-Petronela Radan1, Patricia Renz1,2, Luigi Raio1
1Department of Obstetrics and Feto-Maternal Medicine, University Hospital of Bern, University of Bern, Bern, Switzerland.
Frontiers in medicine
|September 19, 2024
概括
在孕妇中严重的SARS-CoV-2感染可能导致死产. 这项研究发现胎盘中活跃的病毒复制,与死产的严重程度和母亲的症状相关,突出了胎盘的作用.
科学领域:
- 产科和妇科 产科和妇科
- 传染性疾病 传染性疾病
- 病理学 病理学 病理学
背景情况:
- 孕妇面临SARS-CoV-2感染的更高风险,包括早产和死产.
- 了解SARS-CoV-2对胎盘的影响对于孕产妇和新生儿的结果至关重要.
研究的目的:
- 为了调查由SARS-CoV-2引起的胎盘组织损伤.
- 为了确定病毒复制是否发生在胎盘中.
- 为了将胎盘损伤和病毒复制与不良妊娠结果 (如死胎) 相关联.
主要方法:
- 来自61名感染SARS-CoV-2的孕妇和10名对照的胎盘的未来收集.
- 组织病理学,免疫组织化学和实地杂交分析.
- 对SARS-CoV-2蛋白质,ACE2,免疫细胞和病毒基因表达的评估.
主要成果:
- SARS-CoV-2复制得分与母亲的症状严重程度和死产相关.
- 十五个胎盘显示复制;三个死胎病例有最大的复制.
- 在COVID-19患者中,ACE2表达更高;免疫细胞表达没有显著差异.
结论:
- 在胎盘中发现了活体SARS-CoV-2复制的证据.
- 较高的病毒复制强度与严重的母体COVID-19和胎盘炎相关.
- 死亡出生病例的最大复制表明胎盘直接参与胎儿死亡.
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