对用于质子疗法的商业合成计算机断层扫描解决方案的治疗场所特定评估
Ping Lin Yeap1,2, Yun Ming Wong1,3, Kang Hao Lee1
1Division of Radiation Oncology, National Cancer Centre Singapore, Singapore.
Physics and imaging in radiation oncology
|September 19, 2024
概括
选择正确的合成计算机断层扫描 (sCT) 算法对于准确的质子疗法剂量重新计算至关重要. 特定位置的算法选择提高了准确性,特别是在头和骨盆治疗中.
科学领域:
- 医学物理 医学物理
- 辐射疗法 辐射疗法
- 图像处理 图像处理
背景情况:
- 质子疗法提供了优越的剂量一致性,但对每天的解剖学变化敏感.
- 精确的剂量分配对于有效和安全的质子疗法治疗非常重要.
研究的目的:
- 为了评估两个合成计算机断层扫描 (sCT) 生成算法的剂量重新计算精度.
- 在质子疗法中为sCT算法选择提供特定地点的建议.
主要方法:
- 使用两种sCT算法 (corrCBCT和vCT) 对比剂量重新计算的准确性与"基本真相"变形的CTs.
- 通过30名患者的数据,评估了头部和部,胸部和腹部和骨盆部位的算法.
- 使用圆束计算断层扫描 (CBCT) 扫描用于sCT生成.
主要成果:
- 算法选择显著影响了剂量重新计算的准确性,特别是在高剂量区域.
- corrCBCT对头部和部表现出更好的一致性,而vCT对胸部和腹部和骨盆表现更好.
- 头部和部和骨盆的病例显示出很好的一致性 (>98%的2D/2mm马通过率),而胸部和腹部则显示出更大的差异.
结论:
- 在质子疗法中为sCT算法选择制定了特定地点的建议.
- 通过指导算法选择,研究结果支持质子束中心的自适应性放射治疗工作流.
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