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人工智能产生的目标和观察者之间的变化在膀癌的在线自适应性放射治疗中
Lina M Åström1,2, Patrik Sibolt1, Hannah Chamberlin3
1Department of Oncology, Copenhagen University Hospital - Herlev and Gentofte, Copenhagen, Denmark.
Physics and imaging in radiation oncology
|September 19, 2024
概括
膀癌在线适应性放射治疗中的每日目标重新划定显示出显著的观察者之间的差异. 人工智能轮需要手动调整,以确保准确覆盖地面真相目标.
科学领域:
- 辐射瘤学 辐射瘤学
- 医疗成像医学成像
- 人工智能在医学中的应用
背景情况:
- 在线适应性放射治疗 (oART) 中每日目标重新划定引入了不确定性.
- 精确的轮对于膀癌治疗中有效的辐射输送至关重要.
研究的目的:
- 为了评估人工智能 (AI) 为膀瘤生成的轮.
- 为了评估在形光束CT (CBCT) 引导的oART中放射治疗技术人员之间的观察者间的变化.
主要方法:
- 人工智能分段膀轮 (CTV-TAI) 被7名技术人员 (CTV-TADP) 审查和编辑.
- 轮与地面真相 (CTV-TGT) 进行了比较,使用了体积,子相似性和距离指标.
- 对于使用CTV-TAI和CTV-TADP进行优化计划,评估了CTV-TGT的剂量覆盖率.
主要成果:
- 人工智能轮显示,与地面真相相比,体积差异的中位数为-15.5厘米3.
- 手动调整 (CTV-TADP) 导致中位数体积差异为4.5厘米3.
- 在68/70计划中使用手动调整的轮实现了足够的剂量覆盖地面真相目标,而在6/10计划中仅使用AI轮实现了足够的剂量覆盖.
结论:
- 针对膀癌的CBCT导向oART的目标重新划定表现出显著的观察者间变异性.
- 人工智能生成的轮的手动调整对于确保充分覆盖地面真相目标至关重要.
相关概念视频
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Adaptive Mechanisms in Cancer Cells
Cancer cells accumulate genetic changes at an abnormally rapid rate due to the defects in the DNA repair mechanisms. From an evolutionary perspective, such genetic instability is advantageous for cancer development. Mutant cell lines accumulate a series of beneficial mutations that contribute to their progression into cancer.
Some of the advantages that cancer cells have on normal cells include - enhanced ability to divide without terminally differentiating, induce new blood vessel formation,...
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