呼吸道肌肉力量训练可以降低阻塞性睡眠呼吸暂停综合征男性的氧化应激和全身炎症:双盲随机并行试验
Nurel Erturk1, Adem Celik2, Sevim Kahraman Yaman3
1Department of Physiotherapy and Rehabilitation, Faculty of Health Sciences, Tarsus University, Mersin, Turkey.
高强度呼吸肌肉力量训练 (EMST) 在男性患者中显著改善了阻塞性睡眠呼吸暂停综合征 (OSAS) 的严重程度. 这种有效的肺部康复方法显示出减少疾病影响和炎症的前景.
科学领域:
- 呼吸系统医学 呼吸系统医学
- 睡眠医学 睡眠医学
- 肺部康复治疗 肺部康复治疗
背景情况:
- 阻塞性睡眠呼吸暂停综合征 (OSAS) 的特点是睡眠期间发生呼吸事件.
- 系统性炎症和氧化应激与OSAS病变发生有关.
- 呼吸道肌肉力量训练 (EMST) 是一种潜在的治疗干预措施.
研究的目的:
- 为了比较高强度与低强度EMST对OSAS的影响.
- 评估EMST对疾病严重程度,炎症,氧化应激和呼吸肌肉强度的影响.
- 评估EMST对运动能力,症状,嗜睡,疲劳和睡眠质量的影响.
主要方法:
- 这是一项双盲,随机,并行研究,涉及31名中度OSAS男性患者.
- 患者被分配到高EMST或低EMST组,每天进行12周的训练.
- 测量包括多睡眠学 (呼吸暂停-呼吸暂停指数[AHI]),呼吸肌肉强度,以及炎症和氧化应激的血清标志物 (TOS,OSI,TNF-α,IL-6).
主要成果:
- 与低EMST (6.3%) 相比,高EMST显示了AHI (50.8%) 的显著减少.
- 增加的最大呼气压 (MEP) 与降低的AHI相关,增加的AHI与增加的氧气脱度指数 (ODI) 相关.
- 这两种训练强度同样降低了TOS,OSI,TNF-α和IL-6水平.
结论:
- EMST有效降低全身炎症和氧化应激,增强中度OSAS的男性患者的呼吸肌肉力量.
- 高强度EMST在改善疾病严重程度方面优于低强度EMST.
- 在中度的OSAS中,EMST为肺部康复提供了一个实用,有效和有前途的选择.
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