在精神分裂症中改变非快速眼动睡眠的频谱
Nataliia Kozhemiako1, Chenguang Jiang2, Yifan Sun2
1Department of Psychiatry, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, USA.
Sleep
|September 19, 2024
概括
精神分裂症 (SCZ) 睡眠缺陷在患者之间有显著差异,药物治疗方案比临床或认知因素更为促进这种变化. 这些发现突出了SCZ中N2睡眠变化的频谱.
科学领域:
- 神经科学是一个神经科学.
- 睡眠医学 睡眠医学
- 精神病学是一个精神病学.
背景情况:
- 精神分裂症 (SCZ) 与睡眠神经生理学的改变有关,包括非快速眼动 (NREM) 螺旋和缓慢的振荡.
- 之前的研究发现了SCZ患者和对照者之间NREM睡眠指标的群体水平差异,但患者对患者的变化仍然不明.
研究的目的:
- 复制SCZ中之前报告的小组级NREM睡眠差异.
- 描述SCZ群体内NREM睡眠指标患者对患者的变化程度.
- 研究NREM睡眠变化与临床因素,衰老,认知和药物治疗之间的关系.
主要方法:
- 利用高密度睡眠电脑脑图 (EEG) 数据从103名SCZ患者和68名对照者.
- 在N2睡眠阶段指标中复制的组级差异.
- 在175名SCZ患者和126名对照组合样本中分析了患者对患者的变异性 (总N=301).
主要成果:
- 在SCZ患者和对照人群之间复制了小组级NREM睡眠差异.
- 与对照组相比,SCZ患者在26%的睡眠指标中显著增加了个体间的变化.
- 药物治疗方案比临床或认知因素对NREM睡眠变化的贡献更大.
- 快速旋密度在SCZ中显示出夸张的与年龄有关的影响,患者表现出更老的预测生物年龄,奥兰扎平加剧了这些影响.
结论:
- 在SCZ患者中存在一系列客观和可扩展的N2睡眠缺陷.
- 这些发现对了解SCZ.的病因异质性有影响.
- 抗精神病药物治疗方案,特别是 olanzapine,可能会导致SCZ睡眠神经生理学上的阳效应.
更多相关视频
08:20Measuring Neural Mechanisms Underlying Sleep-Dependent Memory Consolidation During Naps in Early Childhood
Published on: October 2, 2019
11.9K
06:23A Chronic Sleep Fragmentation Model using Vibrating Orbital Rotor to Induce Cognitive Deficit and Anxiety-Like Behavior in Young Wild-Type Mice
Published on: September 22, 2020
5.3K
相关概念视频
01:24Sleep-Wake Cycles
1.2K
Sleep is an essential physiological process vital to maintaining overall well-being. The reticular activating system (RAS), a network of neurons in the brainstem, regulates wakefulness and sleep. While it may seem passive, sleep consists of distinct cycles, each with its unique characteristics and functions. Two key sleep phases are non-rapid eye movement (NREM) and rapid eye movement (REM).
NREM Sleep
NREM sleep comprises four progressive stages that seamlessly merge:
NREM Sleep
NREM sleep comprises four progressive stages that seamlessly merge:
1.2K
01:22Stages of Sleep
176
Sleep progresses through distinct stages, each characterized by specific brain wave patterns and physiological responses ranging from wakefulness to stages of non-rapid eye movement, known as non-REM, to rapid eye movement, referred to as REM. Understanding these stages helps in recognizing how sleep supports various bodily and cognitive functions.
Before sleep begins, in wakefulness, the brain exhibits primarily beta waves, which are high in frequency and low in amplitude, indicating alertness...
Before sleep begins, in wakefulness, the brain exhibits primarily beta waves, which are high in frequency and low in amplitude, indicating alertness...
176
01:15REM Sleep Behavior Disorder
161
REM Sleep Behavior Disorder (RBD) is a sleep disorder characterized by the absence of muscle paralysis that normally occurs during the REM phase of sleep. This absence allows individuals to physically act out their dreams, which are often vivid and disturbing. Common behaviors exhibited during episodes include kicking, punching, and yelling. These actions can be dangerous, potentially leading to injuries for the person with RBD or their bed partner.
RBD is significantly associated with...
RBD is significantly associated with...
161
01:07Narcolepsy
94
Narcolepsy is a chronic sleep disorder characterized by pervasive, uncontrolled sleepiness and other sleep disturbances. One of its hallmark symptoms is an abrupt transition to REM sleep upon falling asleep, which causes symptoms typically associated with this phase to occur unexpectedly during wakefulness. These include the following symptoms, which typically last from a minute or two to half an hour.
94
01:27Restless Leg Syndrome and Night Terrors
154
Restless Leg Syndrome (RLS), also known as Willis-Ekbom disease, is a neurological disorder characterized by an uncontrollable urge to move the legs due to uncomfortable sensations. These sensations typically occur during periods of rest or inactivity, particularly when lying down or sitting, and can severely disrupt sleep.
The exact cause of RLS is not fully understood, but it is believed to involve dopamine, a neurotransmitter that helps regulate muscle movement. Imbalances in dopamine levels...
The exact cause of RLS is not fully understood, but it is believed to involve dopamine, a neurotransmitter that helps regulate muscle movement. Imbalances in dopamine levels...
154
01:19Management of Insomnia
235
The sleep cycle, an integral part of human health, consists of several stages with distinct characteristics and functions. It begins with a transition from wakefulness to sleep, known as the light sleep phase, followed by the restorative deep sleep phase, essential for physical recovery and growth. The cycle concludes with the Rapid Eye Movement (REM) phase, characterized by high brain activity and vivid dreaming. Insomnia, a prevalent sleep disorder, involves difficulty falling asleep, staying...
235