BMP信号通路成员的表达得到了肠道神经原始体的丰富,并且对于斑马鱼肠道神经系统的发展是必需的
Joshua A Moore1,2,3, Rodrigo Moreno-Campos1,3, Arielle S Noah1,3
1Department of Biosciences, Rice University, Houston, Texas, USA.
概括
骨形态遗传蛋白 (BMP) 信号传递在脊椎动物肠道神经系统 (ENS) 的形成中起着至关重要的作用. 这项研究确定BMP5是ENS发育和适当的胃肠道殖民化所必需的新型因素.
科学领域:
- 发育生物学是发展生物学.
- 神经科学是一个神经科学.
- 胃肠病学 胃肠病学
背景情况:
- 脊椎动物肠道神经系统 (ENS) 对胃肠道功能至关重要.
- 肠神经系统的发育涉及肠神经细胞 (ENCC) 的迁移,增殖和分化.
- 调节ENCC发展的信号因素尚未得到充分理解.
研究的目的:
- 调查骨形态遗传蛋白 (BMP) 信号传导在ENS发育中的作用.
- 为了确定参与肠道神经系统形成的新信号因子.
主要方法:
- 在斑马鱼中进行转录基因分析.
- 在现场转录表达和免疫组织化学分析.
- 化学减弱和产生bmp5突变/的斑马鱼.
主要成果:
- BMP信号在维持肠道原始细胞数量和分化时间方面具有时间依赖的作用.
- 在ENCCs中确定了新的ENS连接体编码转录bmp5.
- 对于适当的消化道殖民,BMP5在功能上是必需的,如果它不存在,就会观察到原始细胞数量减少.
结论:
- BMP信号对于脊椎动物ENS形成至关重要.
- BMP5是一种新发现的外在因素,对ENS发育至关重要.
关键词:
在BMP中,BMP是BMP.bmp5bmp5bmp5bmp5bmp5bmp5bmp5bmp5bmp5bmp5bmp5bmp5bmp5bmp5bmp5bmp5bmp5bmp5bmp5bmp肠道神经系统 肠道神经系统肠道神经系统的发育和发展肠道神经峰 肠道神经峰斑马鱼是一种斑马鱼.更多相关视频
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