妇女肝硬化的全球流行病学
Gabrielle Jutras1, Jennifer A Flemming2,3
1Division of Hepatology, Department of Medicine, Centre Hospitalier de L'Université de Montréal, Montreal, Quebec, Canada.
The American journal of gastroenterology
|September 19, 2024
概括
肝硬化在全球范围内正在上升,女性的发病率在女性中增长得更快. 性别特异性因素推动了这些趋势,需要量身定制的干预措施,以便在女性患者中获得更好的结果.
科学领域:
- 肝病学 肝病学是一种肝病学.
- 流行病学 流行病学
- 性别特异性医学是一种性特异性医学.
背景情况:
- 在过去的二十年中,全球肝硬化负担显著增加.
- 女性表现出独特的风险因素和对慢性肝病的易感性,需要性别特定的管理策略.
研究的目的:
- 审查肝硬化病的流行病学趋势.
- 探索影响全球性肝硬化的性别特异性因素在女性患者中.
主要方法:
- 审查最近的流行病学证据.
- 全球肝硬化发病率和流行率数据的分析.
- 检查性别特异性风险因素和病因趋势.
主要成果:
- 虽然男性患者的全球患病率仍然较高,但肝硬化发病率在2010-2019年期间在女性中增长得更快.
- 与代谢功能障碍相关的脂肪性肝病相关的肝硬化发病率在2019年在全球范围内超过男性 (1.3比率).
- 与酒精相关的肝硬化发病率正在性别平等,特别是在工业化国家;病毒性肝炎仍然是流行地区的关键原因.
结论:
- 流行病学趋势显示出对女性的转变,特别是在与代谢功能障碍相关的脂肪性肝病相关的肝硬化中.
- 风险因素,易感性和行为方面的多因素性差异有助于肝硬化流行病学.
- 需要进一步的研究,以开发针对性别的干预措施,以改善女性肝硬化管理和以患者为中心的护理.
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