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Updated: Jul 18, 2026

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在寻找难以捉摸的细胞核-DNA传感器

Diane Mathis1

  • 1Department of Immunology, Harvard Medical School, Boston, MA 02115.

Proceedings of the National Academy of Sciences of the United States of America
|September 19, 2024
PubMed
概括

陈志强发现了循环GMP-AMP合成酶 (cGAS) 酶,该酶检测细胞中的DNA并触发免疫反应. 这一突破解释了DNA如何激活天生的免疫力,提供了新的治疗途径.

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Labeling DNA Probes03:31

Labeling DNA Probes

DNA probes are fragments of DNA labeled with a reporter tag to enable their detection or purification. The resulting labeled DNA probes can then hybridize to target nucleic acid sequences through complementary base-pairing, and may be used to recover or identify these regions.
Radioisotopes, fluorophores, or small molecule binding partners like biotin or digoxigenin, are the most widely used reporter tags for labeling DNA probes. These labels can be attached to the probe DNA molecule via...