与没有SCD的黑人美国人相比,患有状细胞疾病 (SCD) 的黑人美国人表现出加速的表观遗传衰老步伐
Melanie E Garrett1, Brandon Le1, Kyle J Bourassa2,3
1Duke Molecular Physiology Institute, Duke University Medical Center, Durham, North Carolina, USA.
概括
状细胞疾病 (SCD) 加快生物衰老,患者每年大约增长0.7个月. 表观遗传衰老措施可能有助于识别SCD患者,这些患者将从减少死亡率的干预中获益最多.
科学领域:
- 遗传学和表观遗传学
- 血液学 血液学 血液学
- 衰老研究研究 衰老研究
背景情况:
- 状细胞病 (SCD) 是一种慢性疾病,导致末端器官损伤,并由于红细胞状和血管封闭而降低存活率.
- 在SCD中显著的病理生理学和早期死亡率表明了加速生物衰老的潜力.
研究的目的:
- 测试SCD患者体验加速生物衰老的假设,与没有SCD的个人相比.
- 为了比较SCD患者和使用DunedinPACE测量的对照组之间的表观遗传衰老速度.
主要方法:
- 使用DunedinPACE测量来评估表观遗传衰老.
- 131名患有SCD的美国黑人与1391名没有SCD的美国黑人退伍军人进行了比较.
主要成果:
- 与对照组相比,SCD患者的衰老速度明显加快 (在DunedinPACE中平均差异为0.057分).
- 与非SCD患者相比,SCD患者每年老化时间大约比SCD患者多0.7个月,尽管他们在时间上更年轻.
- 当患有PTSD的个体被排除在非SCD组之外,当分析具有特定基因型 (血红蛋白SS和Sβ0血症) 的SCD患者时,SCD和加速衰老之间的关联得到了加强.
结论:
- 这些发现支持SCD与加速生物衰老相关的假设,这是全球表观遗传变异所表明的.
- 生物衰老的表观遗传测量可能是识别SCD患者的宝贵工具,这些患者将从旨在降低死亡率的干预中获益最多.
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