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Updated: Jun 12, 2025

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疼痛机制网络:使用监督多变量数据分析的发展和慢性疼痛的影响

Rocco Giordano1,2, Lars Arendt-Nielsen2,3,4,5, Maria Carla Gerra6

  • 1Department of Oral and Maxillofacial Surgery, Aalborg University Hospital, Aalborg, Denmark.

Pain
|September 19, 2024
PubMed
概括

膝关节手术后的慢性术后疼痛涉及复杂的机制. 这项研究使用了网络分析来确定导致持续疼痛的关键因素,解释了疼痛变化的81%.

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Pain is critical to various clinical pathologies, provoking an urgent need for effective management. Pain, whether acute or chronic, is a complex neurochemical process. Its alleviation depends on the type, with nonopioid analgesics effective for mild to moderate pain, such as musculoskeletal or inflammatory pain, while neuropathic pain responds best to anticonvulsants, tricyclic antidepressants, or serotonin/norepinephrine reuptake inhibitors. For severe acute or chronic pain, opioids may be...
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Pain serves as a critical warning signal that alerts the body to potential or actual harm. When mechanical pressure on the skin is intense, such as from a sharp pinch, the sensation transitions from touch to pain. Similarly, extreme temperatures, like a hot pot handle, convert the sensation of heat into pain. Pain can also result from overstimulation of other senses, such as blinding light, loud noise, or the intense heat from habañero peppers. This ability to sense pain is essential for...
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Nociception—the ability to feel pain—is essential for an organism’s survival and overall well-being. Noxious stimuli such as piercing pain from a sharp object, heat from an open flame, or contact with corrosive chemicals are first detected by sensory receptors, called nociceptors, located on nerve endings. Nociceptors express ion channels that convert noxious stimuli into electrical signals. When these signals reach the brain via sensory neurons, they are perceived as pain.
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