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在癌症患者中预测性呼吸障碍对甲和安慰剂反应的生物标志物

David Hui¹, Sandra K Hanneman², Kristofer Jennings³

¹Department of Palliative (D.H., A.O., E.B.), Rehabilitation and Integrative Medicine, The University of Texas MD Anderson Cancer Center, Houston, Texas, USA; Department of General Oncology (D.H.), The University of Texas MD Anderson Cancer Center, Houston, Texas, USA.

Journal of pain and symptom management

|September 19, 2024

概括

较高的基线炎症标志物,如TNF,IL-6,IL-8和IL-10,可以预测哪些癌症患者可以从甲治疗喘息中受益.

科学领域:

在瘤学瘤学.
临床药理学临床药理学
免疫学免疫学免疫学

背景情况:

在癌症患者用德克萨米他 (ABCD) 缓解呼吸困难的试验中,德克萨米他在未经选择的癌症患者中对呼吸障碍无效.
调查炎症标志物可能会揭示受益于德克萨米他的患者子组.

研究的目的:

为了确定基线细胞因子水平是否预测癌症患者对德克萨米他的呼吸障碍反应.
探索特定细胞因子与治疗结果之间的关联.

主要方法:

对ABCD试验 (NCT03367156) 的二次分析,其中涉及甲松与安慰剂.
测量了TNF,IL-6,IL-8和IL-10的基线,7日和14日水平.
使用了通用添加模型来评估细胞因子与呼吸障碍相关的变化.

主要成果:

与安慰剂相比,甲降低了TNF,IL-6和IL-8水平.
较低的基线TNF与与安慰剂更大的呼吸障碍减少相关.
较高的基线TNF,IL-6,IL-8和IL-10与使用德甲更大的呼吸障碍减轻相关.

结论:

甲胺治疗时,细胞因子水平下降.
基线上提升的细胞因子可以识别癌症患者可能对德克萨米他对呼吸障碍的缓解有反应.
炎症标志物可以指导个性化德甲治疗.

关键词:

生物标志物生物标志物皮质类固醇是一种皮质类固醇.细胞因子 (cytokines) 是一种细胞因子.呼吸障碍呼吸障碍呼吸障碍炎症炎症是一种炎症.这些都是新生儿瘤.

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