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变化的角质整形指示:过去二十年的单心分析
Jan Vincent Hoffmann1, Paola Kammrath Betancor2, Philip Maier2
1Eye Center, Medical Center, University Freiburg, Killianstraße 5, 79106, Freiburg im Breisgau, Germany. jan.v.hoffmann@uniklinik-freiburg.de.
概括
状角膜整形术,特别是德塞梅特的膜内皮角膜整形术 (DMEK),已经在很大程度上取代了透式角膜整形术 (PK) 对于富克内皮缩症. 对于其他条件来说,PK仍然是必不可少的,需要继续提供接种剂.
科学领域:
- 眼科医生 眼科 眼科
- 角膜移植 角膜移植
- 公共卫生 公共卫生
背景情况:
- 像DSAEK和DMEK这样的状角膜整形技术已经进步,影响了角膜移植实践.
- 演变的形状的管理策略,包括隐形眼镜和CXL,影响形状的指示.
- 转向更少的侵入性手术已经重塑了角膜手术的景观超过二十年.
研究的目的:
- 在20年的时间里,分析皮整形手术程序及其指示的趋势.
- 评估状角质整形与透角质整形之间不断变化的作用.
- 确定角膜移植在第三级护理环境中的主要驱动因素.
主要方法:
- 从角膜银行和眼睛中心收集匿名电子数据的回顾性分析.
- 数据范围从2004年1月到2023年12月,涵盖了7130例角膜移植.
- 专注于外科手术技术 (PK,DMEK) 和特定指示 (FED,KC,BK).
主要成果:
- 透性角膜整形 (PK) 从95% (2004年) 降至11% (2023年);DMEK从48% (2012) 增加到82% (2023年).
- 福克斯内皮质变质症 (FED) 成为主要的指示 (2004年为24%,到2023年为72%),而角质 (KC) 则下降了 (25%至4%).
- 基因基因表征从BK,FED,KC转变为KC,移植失败,痕和;重复基因基因增加.
结论:
- 在过去二十年中观察到的角质整形技术和指示的显著演变.
- 对于内皮细胞疾病,DMEK非常有效;对于各种指示,PK仍然至关重要.
- 角质银行必须确保所有技术的接供应充足,预测未来的需求,特别是重复程序.
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