导电性水凝的光纹,这些水凝具有类似组织的特性
Léo Sifringer1, Lina De Windt1, Stéphane Bernhard2
1Laboratory of Biosensors and Bioelectronics, Institute for Biomedical Engineering, ETH Zürich, Switzerland. ct81@rice.edu.
Journal of materials chemistry. B
|September 19, 2024
概括
研究人员使用石墨烯片开发了导电性水凝,用于神经组织工程. 这些超软的,有图案的支架支持神经元生长超过7周,使先进的神经接口.
科学领域:
- 生物材料科学 生物材料科学
- 神经科学是一个神经科学.
- 材料工程 材料工程 材料工程
背景情况:
- 水凝是模拟细胞外矩阵的可调整3D材料,广泛用于细胞培养.
- 导电性水凝可以调节像神经元这样的电活性细胞,并通过多电极阵列与组织接口.
研究的目的:
- 为神经组织工程创建具有可调节性质的导电水凝.
- 开发有图案的支架来支持神经细胞生长和创建超软电极.
主要方法:
- 石墨烯片被机械悬浮在水凝前体中以达到导电性.
- 凝甲基酸盐水凝被用光吸收剂与复杂的图案相交连接.
- 人类诱导的多能干细胞衍生的感觉神经元被培养在脚手架上.
主要成果:
- 随着石墨烯片的百分比提高,水凝的导电性增加,保持了类似组织的机械性能.
- 光交联的水凝支持感官神经元生长超过7周,持续活力.
- 有图案的支架展示了神经接口中超软电极的潜力.
结论:
- 导电性,有图案的水凝为神经组织工程提供了一个有前途的平台.
- 这些材料可以用于先进的多电极阵列,用于体外和体内神经相互作用.
- 开发的支架为改善神经接口提供了与组织匹配的特性.
相关概念视频
Cohesion
Cohesion is the attraction between molecules of the same type, such as water molecules. Water molecules have an overall neutral charge but are polar molecule. An oxygen atom in one water molecule has a partial negative charge that can bind to a hydrogen atom with a partial positive charge in a second water molecule, forming a hydrogen bond. Each water molecule can form up to four hydrogen bonds with other water molecules. Hydrogen bonds are responsible for water's cohesive nature.
On a surface,...
On a surface,...
Molecular Shape and Polarity
Dipole Moment of a Molecule
Intermolecular Forces
Atoms and molecules interact through bonds (or forces): intramolecular and intermolecular. The forces are electrostatic as they arise from interactions (attractive or repulsive) between charged species (permanent, partial, or temporary charges) and exist with varying strengths between ions, polar, nonpolar, and neutral molecules. The different types of intermolecular forces are ion–dipole, dipole–dipole, hydrogen bonds, and dispersion; among these, dipole–dipole, hydrogen bonds, and dispersion...
Solubility
Solution, Solubility, and Solubility Equilibrium
A solution is a homogeneous mixture composed of a solvent, the major component, and a solute, the minor component. The physical state of a solution—solid, liquid, or gas—is typically the same as that of the solvent. Solute concentrations are often described with qualitative terms such as dilute (of relatively low concentration) and concentrated (of relatively high concentration).
In a solution, the solute particles (molecules, atoms, and/or ions)...
A solution is a homogeneous mixture composed of a solvent, the major component, and a solute, the minor component. The physical state of a solution—solid, liquid, or gas—is typically the same as that of the solvent. Solute concentrations are often described with qualitative terms such as dilute (of relatively low concentration) and concentrated (of relatively high concentration).
In a solution, the solute particles (molecules, atoms, and/or ions)...
Preparation of Samples for Electron Microscopy
To be visualized by an electron microscope, either transmission or scanning, biological samples need to be fixed (stabilized) so the electron beam does not destroy them and dried thoroughly (desiccated/dehydrated) so the vacuum does not affect them. Fixation needs to be done as quickly as possible because the sample properties will start changing as soon as it is removed from its natural environment. For example, in a tissue sample, the oxygen levels begin decreasing, causing an altered...
Coagulation
Colloidal solids are solid particles suspended in solution. They are usually negatively charged, attracting a compact primary layer of positively charged ions, which attract more counterions to form an electrical double layer. Electrostatic repulsion between the charged double layers prevents the particles from colliding, stabilizing the colloids. These solids are often undesirable because they can contain toxins that are difficult to remove. Coagulation is a technique that helps aggregate and...


