主观认知和嗅觉障碍预测不同的潜在痴呆症结果
Nira Cedres1,2,3, Jonas K Olofsson1
1Department of Psychology, Sensory Cognitive Interaction Laboratory (SCI-Lab), Stockholm University, Stockholm, Sweden.
Chemical senses
|September 19, 2024
概括
自我报告的措施,如主观认知衰退和嗅觉障碍,可以预测痴呆风险. 这些可访问的工具有助于在一般人群中早期发现阿尔茨海默氏症,帕金森症和其他痴呆症.
科学领域:
- 神经科学是一个神经科学.
- 老年学是一门学科.
- 公共卫生 公共卫生
背景情况:
- 自我报告的措施越来越多地被认为具有早期疾病检测的潜力.
- 痴呆症,包括阿尔茨海默病 (AD) 和帕金森病 (PD),构成了重大的公共卫生挑战.
- 早期识别有风险的个体对于及时干预和管理至关重要.
研究的目的:
- 调查不同痴呆症亚型的各种自我报告措施的预测价值.
- 评估进展到阿尔茨海默病 (AD) 痴呆症,帕金森病 (PD) 痴呆症或其他原因痴呆症的风险.
- 确定主观认知衰退 (SCD),主观嗅觉障碍 (SOI),主观味觉障碍 (STI) 和自我报告的健康状况不佳 (SPH) 在痴呆风险预测中的有用性.
主要方法:
- 作为基线,利用了英语长度老化研究 (ELSA) 第八波的6,028名认知无障碍个体的数据.
- 包括来自ELSA第九波的5,297个人的2年随访样本.
- 采用后勤回归模型来分析自我评估措施与痴呆症结果之间的关联,控制年龄.
主要成果:
- 基于记忆问题的主观认知衰退 (SCD) 显著预测到AD痴呆症 (OR=11.145) 和其他原因痴呆症 (OR=4.448) 的进展.
- 主观嗅觉障碍 (SOI) 显著预测了PD痴呆症的进展 (OR=7.440).
- 高龄是所有痴呆症结果的重要预测因素,非记忆认知投诉也预测了其他原因的痴呆症.
结论:
- 自我报告的措施,特别是SCD和SOI,是识别有特定痴呆类型风险的个体的有价值和可访问的工具.
- 这些主观评估,结合年龄等人口因素,可以帮助在一般人群中进行早期痴呆查.
- 不同的主观投诉与不同的痴呆症结局特别相关,突出显示了它们的有针对性的预测潜力.
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