催产素和多巴胺相关基因与信任之间的表观相互作用
Yuna Koyama1, Nobutoshi Nawa1, Manami Ochi2,3
1Department of Public Health, Tokyo Medical and Dental University (TMDU), Tokyo, Japan.
PloS one
|September 19, 2024
概括
遗传相互作用影响信任. 催产素和多巴胺系统中的特定基因变异与性别相结合,会影响邻居和机构信任,特别是在男性中.
科学领域:
- 神经科学是一个神经科学.
- 行为遗传学 行为遗传学
- 社会心理学 社会心理学
背景情况:
- 信任是人类的一个基本特征,对社会凝聚力至关重要.
- 催化素和多巴胺系统与信任形成有关.
- 与这些系统相关的基因之间的表观相互作用及其对信任的影响仍未得到充分探索.
研究的目的:
- 研究催产素和多巴胺相关基因之间的基因-基因 (表观性) 相互作用,对一般,社区和机构信任产生影响.
- 检查性别差异在这些遗传关联中的作用.
- 识别特定的遗传变异及其对信任的综合影响.
主要方法:
- 对参与者 (N=348,114名男性) 的基因定型,以检测催产素受体基因 (OXTR) 和多巴胺相关基因 (COMT,DRD2) 的变异.
- 对不同信任度的基因型和性别之间的三向相互作用进行统计分析.
- 性别分层分析和后期测试以确定有意义的关联.
主要成果:
- 在OXTR rs1042778,COMT rs4680基因型和性别 (p=0.02) 之间发现了显著的三向相互作用.
- 在OXTR rs2254298,DRD2 rs1800497基因型和性别 (p=0.01) 之间出现了另一种三向相互作用.
- 在男性中,特定的OXTR-COMT基因组合预测了社区信任 (p=0.0007),而OXTR-DRD2组合预测了机构信任 (p=0.005). 在女性中没有发现相互作用.
结论:
- 催产素和多巴胺相关基因之间的表观相互作用,由性别调节,显著影响特定类型的信任.
- 这些发现突出了信任的复杂遗传基础,在男性中观察到明显的影响.
- 需要进一步的研究来验证这些发现,并探索涉及到的精确机制.
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