密RNA编码PTEN对骨髓瘤临床病理特征和预后的影响:系统性审查和元分析
Edward Kurnia Setiawan Limijadi1, Robin Novriansyah2,3, Danendra Rakha Putra Respati3,4
1Department of Clinical Pathology, Faculty of Medicine, Universitas Diponegoro, Semarang, Indonesia.
PloS one
|September 19, 2024
概括
微RNA (miRNA) 和PTEN表达水平是骨髓瘤 (OSC) 预后的重要指标. 高的miRNA和低的PTEN表达与OSC患者的不良结果相关,突出了它们作为生物标志物的潜力.
科学领域:
- 在瘤学瘤学.
- 分子生物学分子生物学
- 生物标志物发现发现
背景情况:
- 骨髓瘤 (OSC) 是青少年患有预后不佳的常见骨癌.
- 改进的预后工具对于提高OSC患者的生存率至关重要.
研究的目的:
- 调查微RNA (miRNA) 编码的PTEN在骨髓瘤中的临床病理意义.
- 评估OSC中miRNA和PTEN表达的预后价值.
主要方法:
- 2013年至2023年间发表的17项临床横截面研究的系统审查和元分析.
- 根据PRISMA指导方针,从六个数据库 (Scopus,PubMed,ProQuest,Science Direct,Sage Pub,Cochrane) 中提取的数据.
- 使用ROBINS-I评估偏差风险;根据PICOS标准分析结果.
主要成果:
- 与健康对照组相比,OSC患者的miRNA表达显著增加 (p < 0.00001).
- 在miRNA和PTEN表达之间观察到强烈的反相关性 (p < 0.001) (效果大小-0.681).
- 较低的miRNA表达与骨髓瘤的预后较差显著相关 (p < 0.00001).
结论:
- 十五个miRNAs,以及PTEN表达,显示潜在的骨髓瘤的预后生物标志物.
- 与降低PTEN表达相关的miRNA水平升高表明OSC的预后更差.
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