细胞癌的辅助治疗:目前的情况和未来的情况
David K W Leung1, Brian W H Siu1, Jeremy Y C Teoh1,2,3
1S.H. Ho Urology Centre, Department of Surgery, Prince of Wales Hospital.
Current opinion in urology
|September 19, 2024
概括
辅助布洛利祖马布在细胞癌 (RCC) 患者中显著改善了无疾病和整体存活率. 与以前的治疗方法不同,它是RCC唯一有效的辅助疗法.
科学领域:
- 在瘤学瘤学.
- 免疫治疗是一种免疫疗法.
- 细胞癌研究 细胞癌研究
背景情况:
- 细胞癌 (RCC) 对传统化疗表现出耐药性.
- 之前的辅助疗法,如干扰素和氨酸激酶抑制剂,其疗效有限.
- 免疫检查点抑制剂 (ICI) 是RCC治疗的一个有前途的进步.
研究的目的:
- 总结关于细胞癌辅助治疗的最新证据.
- 评估免疫检查点抑制剂在RCC的辅助设置中的疗效.
主要方法:
- 对细胞癌的辅助疗法最新证据的审查.
- 在RCC中分析KEYNOTE-564试验数据,用于辅助药Pembrolizumab.
- 考虑EAU指导方针和其他辅助ICI试验结果.
主要成果:
- 辅助勃利祖马布在RCC的KEYNOTE-564试验中显示出显著的生存益处.
- 在24个月后,使用Pembrolizumab (77.3% vs. 68.1%) 改善了无疾病生存期 (DFS).
- 在57.2个月的随访期间,Pembrolizumab (HR 0.62) 观察到整体生存 (OS) 的好处.
- 在RCC中进行的其他辅助性ICI试验也产生了负面结果.
结论:
- 布罗利祖马布是目前唯一的辅助疗法,可以为RCC提供生存益处.
- 辅助类氨酸激酶抑制剂和放射治疗不建议用于RCC.
- 多学科方法和共享决策对于RCC患者管理至关重要.
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