广东省精神分裂症患者中抗精神病药物处方模式,中国686计划:一项回顾性研究
Yingji Hu1,2,3, Jinghua Su3,4, Xuanyu Xu1,2,3
1Guangzhou Medical University, Guangzhou, China.
Medicine
|September 19, 2024
概括
在中国的"686计划"中,精神分裂症患者经常接受多种抗精神病药物. 该研究强调,需要对抗精神病多药药 (APP) 进行更多研究,并强调抗精神病单疗法 (AMT) 以改善患者的治疗结果.
科学领域:
- 精神病学和心理健康 精神病学和心理健康
- 药理学和治疗学 药理学和治疗学
- 公共卫生政策 公共卫生政策
背景情况:
- 精神分裂症是一种严重的精神障碍,具有重大公共卫生影响.
- 关于中国严重精神疾病的"686计划"中的抗精神病药物处方模式的数据有限.
- 了解药物使用对于优化国家支持计划中的治疗至关重要.
研究的目的:
- 根据"686计划",调查广东省精神分裂症患者的抗精神病药物使用和处方模式.
- 为了确定与抗精神病多药 (APP) 与抗精神病单疗 (AMT) 相关的因素.
- 为改善中国精神分裂症患者的药物管理策略提供见解.
主要方法:
- 在2019年1月至2019年12月期间,参加"686计划"的1645名出院的精神分裂症患者的回顾性分析.
- 数据收集包括来自医疗记录的临床和社会人口统计信息.
- 统计分析以确定处方模式,APP的流行率和相关预测因素.
主要成果:
- 第二代抗精神病药物 (SGA) 主要被处方 (98.8%),其中RISPERIDONE,OLANZAPINE,CLOZAPINE和AMISULPRIDE是最常见的.
- 60.5%的患者使用抗精神病单疗法 (AMT),而39.5%的患者使用抗精神病多疗法 (APP).
- 预测APP的预测因素包括多次入院,更长的住院时间和修改后的电疗法 (mECT).
结论:
- 在广东省"686计划"下住院的精神分裂症患者经常接受多种抗精神病药物.
- 有必要教育精神病医生关于AMT的好处和与APP相关的风险.
- 进一步的随机对照试验对于确定最佳抗精神病药物组合和确定可能从多药中受益的患者个人资料至关重要.
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