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An Automated Radiosynthesis of [68Ga]Ga-FAPI-46 for Routine Clinical Use
Published on: May 24, 2024
前性研究比较[99mTc]Tc-DP-FAPI 定量SPECT/CT 与[68Ga]Ga-FAPI-04 PET/CT 在患有胃肠道瘤的患者中
Cheng Zhou1, Guoquan Li1, Zhiyong Quan1
1Department of Nuclear Medicine and State Key Laboratory of Holistic Integrative Management of Gastrointestinal Cancers, Xijing Hospital, Fourth Military Medical University, Xi'an, Shaanxi 710000, China.
标有Technetium-99m的纤维细胞激活蛋白抑制剂 ([99mTc]Tc-DP-FAPI) 对初级胃肠道瘤具有很高的敏感性. 虽然[99mTc]Tc-DP-FAPI对于初始查有效,但与-68-标记 ([68Ga]Ga-FAPI-04) 成像相比,它在检测转移方面存在局限性.
科学领域:
- 核医学是一种核医学.
- 在瘤学瘤学.
- 放射化学 放射化学是指辐射化学.
背景情况:
- [68Ga]Ga-FAPI-04 PET/CT已被建立用于瘤成像.
- 标有Tc的纤维细胞激活蛋白抑制剂 (FAPI) 已经显示出安全的生物分布.
- 对于用于瘤成像的TC标记FAPI存在有限的研究.
研究的目的:
- 评估[99mTc]Tc-DP-FAPI在诊断胃肠道瘤中的准确性.
- 将[99mTc]Tc-DP-FAPI的诊断性能与[68Ga]Ga-FAPI-04.4进行比较.
- 评估[99mTc]Tc-DP-FAPI在病变检测和分期方面的实用性.
主要方法:
- 对24名被诊断患有胃肠道瘤的患者进行前性研究.
- 使用[99mTc]Tc-DP-FAPI进行定量SPECT/CT成像.
- 在连续几天使用Ga-FAPI-04进行PET/CT成像.
- 对病变检测灵敏度和特异性的比较分析.
主要成果:
- 无论是[99mTc]Tc-DP-FAPI和[68Ga]Ga-FAPI-04都显示出对初级胃肠道瘤的100%敏感性.
- [99mTc]Tc-DP-FAPI对淋巴结转移的检测显示出低灵敏度 (32.8%) 和特异性 (10.9%).
- 与[99mTc]Tc-DP-FAPI (3转移) 相比,Ga-FAPI-04检测到显著更多的淋巴结 (57) 和远程转移 (9).
- [Ga]Ga-FAPI-04在淋巴结检测方面表现出更高的灵敏度 (89.1%) 和特异性 (67.2%).
结论:
- [99mTc]Tc-DP-FAPI对于检测初级胃肠道瘤非常敏感.
- 虽然[99mTc]Tc-DP-FAPI与[68Ga]Ga-FAPI-04匹配用于初级瘤检测,但它在识别转移方面是有限的.
- [99mTc]Tc-DP-FAPI对于预先查和早期诊断疑似胃肠道瘤具有价值.
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