连接点:在基于人口的队列中,内部化和功能性症状的网络结构
Urvi Saini1, Judith G M Rosmalen2, Albertine J Oldehinkel1
1University of Groningen, University Medical Center Groningen, Department of Psychiatry, Interdisciplinary Center Psychopathology and Emotion Regulation (ICPE), Groningen, the Netherlands.
内化和功能障碍的症状与诸如疲劳和注意力不集中等桥梁症状有关. 这些共同的症状可能解释了这些疾病之间的并发症.
科学领域:
- 精神病学和行为医学
- 临床心理学 临床心理学
- 流行病学 流行病学
背景情况:
- 内化障碍 (ID) 和功能障碍 (FD) 经常同时发生,这表明共享的潜在机制.
- 以前的研究主要集中在疾病级别的并发症上,而症状级别的关系未被充分探索.
- 了解这些症状联系对于阐明连接精神和身体健康状况的途径至关重要.
研究的目的:
- 调查主要抑郁症 (MDD),泛性焦虑症 (GAD),肌痛性脑筋炎/慢性疲劳综合征 (ME/CFS),纤维肌痛 (FM) 和刺激性肠综合征 (IBS) 之间的症状级关系.
- 通过网络方法识别特定的"桥梁症状",将内化和功能障碍连接起来.
- 探索这些桥梁症状在解释IDs和FDs之间的并发症中的作用.
主要方法:
- 利用了来自荷兰生命线队列研究中的72,919名成年人的横截面数据.
- 评估了38个ID和FD的症状,使用验证的问卷.
- 采用网络模型 (Ising模型与eLasso) 来识别症状连接和桥梁症状,使用网络比较测试 (NCT) 来检测性别和年龄差异.
主要成果:
- 症状显示了中度的相互连接 (网络密度为52.7%),ID和FD有不同的集群.
- 连接这两个领域的关键桥梁症状包括疲劳,难以集中注意力,睡眠困难和不清爽的睡眠.
- 疲劳和难以集中注意力是最相关的症状,与其他症状的很大一部分联系在一起. 没有发现网络结构中基于性别或年龄的显著差异.
结论:
- 内化和功能障碍的症状是适度相互关联的.
- 桥梁症状,特别是疲劳和难以集中注意力,在将这些疾病联系起来方面发挥着重要作用.
- 这些发现强调了针对共同症状的重要性,以了解和潜在地治疗伴随性ID和FD.
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