不完整的自由诱导衰变的循环神经网络辅助处理在大脑的H-MRS中发生衰变
Eunho Jeong1, Joon Jang2, Ji-Hoon Kim3
1Department of Applied Bioengineering, Graduate School of Convergence Science and Technology, Seoul National University, Seoul, South Korea.
Journal of magnetic resonance (San Diego, Calif. : 1997)
|September 19, 2024
概括
循环神经网络 (RNN) 可以从不完整的质子磁共振光谱 (1H-MRS) 数据来量化主要的大脑代谢物. 这些先进的神经网络 (NN) 显示出对代谢物量化的承诺,即使数据点显著减少.
科学领域:
- 神经成像是一种神经成像.
- 生物物理学的生物物理.
- 计算神经科学是一种神经科学.
背景情况:
- 质子磁共振光谱 (1H-MRS) 和光谱成像 (1H-MRSI) 经常面临有限的采样或截断的自由诱导衰变 (FID) 的挑战.
- 从不完整的FID中精确量化代谢物对于这些场景中的可靠分析至关重要.
- 循环神经网络 (RNN) 架构非常适合处理像FIDs这样的顺序时间域数据.
研究的目的:
- 研究基于RNN的神经网络 (NN) 的潜力,以在3.0T时从不完整的FID量化人类大脑代谢物.
- 开发和评估两个不同的RNN方法:一个用于FID恢复 (rRNN),另一个用于直接代谢物量化 (cRNN).
- 用模拟和体内数据评估这些NN的性能,重点关注具有最小采样数据点的FID.
主要方法:
- 开发了一个RNN编码器-解码器模型 (rRNN) 来恢复不完整的FID,然后使用LCModel进行代谢物量化.
- 修改了RNN编码器-解码器,通过线性回归直接将不完整的FID转换为仅代谢物的FID (cRNN),用于通过线性回归进行定量分析.
- 在模拟数据上培训了NN,并在27名健康志愿者的体内数据上进行了测试,重点是仅使用前64个数据点的FID.
主要成果:
- 无论是rRNN还是cRNN,都表明了NN衍生和基底真相代谢物含量之间的强烈相关性 (rRNN的R = 0.830.94,cRNN的R = 0.860.91;p ≤0.05) 对于myo-inositol,总胆和总肌酸.
- 在从FIDs获得的代谢物量化中,NNs被证明是有效的,样本数据点大幅减少.
- 低至中等信号噪声比 (SNR) 的代谢物的性能需要进一步改进,可能通过先进的模拟技术.
结论:
- RNN类型的NN显示出从显著低样本的1H-MRS/1H-MRSI数据中量化主要的大脑代谢物的显著潜力.
- 开发的rRNN和cRNN方法在有限的采样窗口的情况下提供了可行的代谢物量化策略.
- 为了提高低SNR代谢物的性能,需要在NN架构和模拟方法方面取得进一步的进步.
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