呼吁有同情心的阿片类药物过量反应
Erin Russell1, Mary Hawk2, Joanne Neale3
1Health Management Associates, 2501 Woodlake Cir Suite 100, Okemos, MI 48864, USA.
The International journal on drug policy
|September 19, 2024
概括
高剂量阿片类药物过量逆转药物风险 戒断. 专家们呼吁社区参与,标准纳洛剂量和富有同情心的护理,优先考虑呼吸而不是戒断.
科学领域:
- 公共卫生 公共卫生
- 药理学 药理学是指药理学的学科.
- 减少伤害 减少伤害
背景情况:
- 高剂量和长期作用的阿片类药物过量逆转药物在阿片类药物依赖的个体中增加了加速戒断的风险.
- 最近在美国推出的产品引发了国际关注,因为可能会导致严重的戒断症状.
- 来自全球纳洛分发计划的现有证据支持使用标准剂量来恢复呼吸而不引起戒断.
研究的目的:
- 解决有关高剂量和长效阿片类抗体及其对阿片类药物戒断的影响的担忧.
- 在开发和分销过量逆转产品时,倡导以患者为中心的方法.
- 为监管机构,制药厂商和减少危害计划提供建议.
主要方法:
- 减少危害专家小组在同情过量反应峰会和纳洛剂量会议 (2024年3月18-19日) 上召开会议.
- 专家小组根据专家的共识和现有证据发布了一份行动呼吁.
- 建议侧重于社区参与,风险沟通,适当的剂量和同情护理.
主要成果:
- 专家建议在产品的研究,开发,选择和分销中直接参与吸毒者.
- 监管机构和制造商应该明确沟通与更高剂量,更长效的抗剂相关的戒断风险.
- 推的拿回家纳洛套件包括至少两剂0.4毫克肌内 (IM) 或≤4毫克鼻内 (IN) 产品.
- 目前,高剂量和长效阿片类抗体被认为不适合急性过量反应.
- 过量剂量反应培训应优先重视恢复呼吸,避免戒断,并提供富有同情心的支持.
结论:
- 标准剂量的纳洛产品对于有效和富有同情心的过量反应至关重要.
- 政府机构应该资助减少危害的计划,以确保标准剂量纳洛的广泛供应.
- 一种富有同情心的方法,强调恢复呼吸并尽量减少戒断,应该指导过量反应和护理的所有方面.
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