双层益生菌封装使用金属网络与凝-塔米兰涂层,用于结肠炎治疗
Xin-Chuang Wang1, Yu Xu2, Wen Jiang1
1SKL of Marine Food Processing & Safety Control, National Engineering Research Center of Seafood, Collaborative Innovation Center of Seafood Deep Processing, School of Food Science and Technology, Dalian Polytechnic University, Dalian 116034, PR China.
International journal of biological macromolecules
|September 19, 2024
概括
一种新的双层封装Lactobacillus plantarum (L.P) 显著提高了其在胃肠道中的生存和功能. 这种改进的益生菌输送系统在治疗炎症性肠病 (IBD) 和其他肠道疾病方面表现有前途.
科学领域:
- 生物材料科学 生物材料科学
- 胃肠病学 胃肠病学
- 微生物学 微生物学
背景情况:
- 口服益生菌疗法已被认可用于治疗炎症性肠病 (IBD).
- 益生菌的有效性受到严重的胃肠道疾病的限制.
- 创新的输送策略对于有效的IBD治疗至关重要.
研究的目的:
- 开发一种新的双层封装策略,用于植物乳杆菌 (L.P).
- 增强益生菌对胃肠道疾病的抵抗力,改善治疗功能.
- 在DSS诱导的大肠炎模型中评估封装益生菌的疗效.
主要方法:
- 封装L.P使用酸-网和糖-糖多糖合物涂层 (L.P-C/T-G/T).
- 评估耐酸性,自由基清除活性和肠道保留时间.
- 在DSS诱导的小鼠结肠炎模型中进行评估,测量结肠缩短,ROS水平和粘液层完整性.
主要成果:
- 双层系统使L.P的抗酸性增加了十倍,自由基的清除能力增加了五倍.
- 封装L.P的肠内保留时间延长了6-12小时.
- 在大肠炎模型中,封装L.P显著缓解了结肠缩短,减少了ROS,并促进了粘液层的修复.
结论:
- 双层封装系统有效地保护和增强益生菌LP的功能.
- 这种先进的益生菌输送技术为治疗大肠炎和其他胃肠道疾病提供了有前途的方法.
- 该战略代表了口服益生菌输送系统的重大进步.
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