相关实验视频

Updated: May 2, 2026

Self-Nanoemulsification of Healthy Oils to Enhance the Solubility of Lipophilic Drugs

Self-Nanoemulsification of Healthy Oils to Enhance the Solubility of Lipophilic Drugs

Published on: July 27, 2022

由大豆蛋白分离物-鲁丁复合物稳定的高内相乳液:风湿学性质,生物可访问性和体外释放动力学

Juyang Zhao¹, Yiyu Chen², Shuo Xu²

¹College of Tourism and Cuisine, Harbin University of Commerce, Harbin, Heilongjiang 150028, China; Postdoctoral Programme of Meteria Medical Institute, Harbin University of Commerce, Harbin 150028, China.

International journal of biological macromolecules

|September 19, 2024

概括

豆蛋白分离剂-素复合物产生稳定的高内部相乳液 (HIPEs),以增强疏水化合物的输送. 这些HIPE显示出改善的负载,生物可访问性和持续释放的rutin.

科学领域:

食品科学食品科学食品科学
材料科学材料科学材料科学
生物技术是生物技术.

背景情况:

高内相乳液 (HIPEs) 是防水生物活性化合物的有效载体.
优化HIPE特性可以提高封装物质的稳定性和生物可访问性.
大豆蛋白分离物 (SPI) 和鲁丁 (SPI-R) 复合物为HIPE稳定提供可调节的特性.

研究的目的:

研究在不同预热温度下形成的SPI-R复合物的使用,以稳定HIPEs.
为了优化HIPE特性 (粒子大小,电荷) 使用不同的均化速率.
评估从稳定的HIPEs中素的加载效率,体外生物可访问性和释放动力学.

主要方法:

在各种预热温度下形成SPI-R复合体.
使用SPI-R复合体稳定HIPE.
通过不同的同质化速率 (例如,15,000rpm) 调整HIPE粒子大小和电荷.
在体外消化测试以评估生物可访问性.
释放动力学分析.

主要成果:

对于SPI-R复合体而言,70°C的最佳预热温度和15,000rpm的同质化速率显著改善了HIPE的稳定性,均性和形学.
在最佳条件下通过SPI-R复合物 (HSR) 稳定HIPE,实现了高常规载荷效率 (98.68%) 和增强生物可访问性.
从HSR中持续释放的鲁丁通过释放动力学研究得到证实.

结论:

SPI-R复合物,特别是那些在70°C形成并用于在15,000rpm创建HIPEs的复合物,是有效的稳定剂.
开发的HSR系统显示了囊和输送水生物活性化合物,如rutin的优良潜力.
这种方法为改善营养药和功能性食品成分的输送和有效性提供了一个有希望的策略.

关键词:

生物可访问性生物可访问性高内部相位乳液是高内部相位乳液.动力释放特征动力释放特征动力释放特征蛋白 - 复合体是一种蛋白质 - 复合体.一个常规的日常生活.

更多相关视频

In vitro Digestion of Emulsions in a Single Droplet via Multi Subphase Exchange of Simulated Gastrointestinal Fluids

In vitro Digestion of Emulsions in a Single Droplet via Multi Subphase Exchange of Simulated Gastrointestinal Fluids

Published on: November 18, 2022

Cellular Affinity of Particle-Stabilized Emulsion to Boost Antigen Internalization

Cellular Affinity of Particle-Stabilized Emulsion to Boost Antigen Internalization

Published on: September 2, 2022

相关概念视频

Bioavailability Enhancement: Drug Stability Enhancement and GI Retention

Bioavailability Enhancement: Drug Stability Enhancement and GI Retention

Improving a drug's stability in the gastrointestinal (GI) tract is paramount for enhancing its bioavailability and therapeutic effectiveness. Various strategies are employed to protect the drug from the harsh gastric milieu and to ensure its release and absorption at the desired site within the GI tract.Polymer coatings are one such method used to shield drugs from the stomach's acidic environment. By preventing premature drug release, these coatings improve the bioavailability of unstable...

Modified-Release Drug Delivery Systems: Bioavailability

Modified-Release Drug Delivery Systems: Bioavailability

Modified-release (MR) dosage forms are designed to extend drug release over time, thereby maintaining stable plasma concentrations and reducing dosing frequency. However, their bioavailability is typically below 100% due to incomplete drug release and presystemic metabolism, and limitations in drug permeability across the gastrointestinal epithelium, all of which can restrict the fraction of the drug reaching systemic circulation. Consequently, studying the in vivo bioavailability of MR...