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在移植患者中传播的Mycobacterium chelonae感染
Mustafa Muwafaq Yaseen1, Sebastian Spencer2, Sunil Bhandari2
1Hull University Teaching Hospitals NHS Trust, Hull, East Riding of Yorkshire, UK mustafamoufaq@gmail.com.
BMJ case reports
|September 19, 2024
概括
两名移植患者患上了传播的Mycobacterium chelonae感染,出现皮肤病变. 有效的治疗包括长期使用克拉里胺/亚齐胺和急性阶段使用线胺/泰吉环素.
科学领域:
- 传染性疾病 传染性疾病
- 腎臟病學 (nephrology) 是一種醫學專業.
- 移植免疫学 移植免疫学
背景情况:
- 快速生长的非结核性菌根菌,如Mycobacterium chelonae (M. chelonae),可以导致传播感染.
- 接受移植的接受者容易因免疫抑制疗法而患上机会性感染.
- 散布的M. chelonae感染可以表现为皮肤感染,特别是在免疫抑制个体中.
研究的目的:
- 描述两名脏移植接受者传播的Mycobacterium chelonae感染的临床表现和治疗结果.
- 突出特定抗生素治疗方案在治疗移植后的M. chelonae感染中的作用.
主要方法:
- 两名患有M. chelonae感染的移植患者的医疗记录的回顾性审查.
- 详细分析患者背景,移植特征,免疫抑制疗法和感染过程.
- 抗生素治疗和临床反应的记录.
主要成果:
- 两名患者都出现了皮肤表现,进展为传播的M. chelonae感染.
- 治疗方案包括澄胺,亚胺,线胺和tigecycline.
- 长期使用克拉里菌素和亚齐菌素在持续治疗中显示出有效性.
- 莱涅佐利德和提格环素在控制急性传播方面有效.
结论:
- 传播的Mycobacterium chelonae感染对移植接受者构成重大风险.
- 组合抗生素治疗,特别是用克拉里素和阿齐素,对于长期管理是有效的.
- 及时开始适当的抗生素对于成功的治疗结果至关重要.
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