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Updated: Jun 12, 2025

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不同的淋巴动力学在自发的内血压下降

H Urbach1, I E Duman Kavus2, C Zander2

  • 1From the Departments of Neuroradiology (H.U., I.E.D.K., C.Z., L.B., E.K., A.R., N.L.), Medical Center-University of Freiburg, Freiburg, Germany horst.urbach@uniklinik-freiburg.de.

AJNR. American journal of neuroradiology
|September 19, 2024
PubMed
概括

淋巴系统通过一个副血管通道清除大脑废物. 自发的内低血压会改变淋巴系统的动力学,影响大脑中的废物清除和对比度分布.

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Physiological pharmacokinetic models, often called flow-limited or perfusion models, typically assume a swift drug distribution between tissue and venous blood, creating a rapid drug equilibrium. This premise is based on the idea that drug diffusion is extremely fast, and the cell membrane presents no barrier to drug permeation. In this scenario, where no drug binding occurs, the drug concentration in the tissue equals that of the venous blood leaving the tissue. This greatly simplifies the...
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