非HACEK 格拉姆阴性细菌感染性内心炎:来自德国回顾性队列研究的数据
Juliane Dörfler1, Herko Grubitzsch2,3, Matthias Schneider-Reigbert4,3,5
1Department of Infectious Diseases, Respiratory Medicine and Critical Care, Charité - Universitätsmedizin Berlin, Corporate Member of Freie Universität Berlin and Humboldt-Universität zu Berlin, Augustenburger Platz 1, 13353, Berlin, Germany.
Infection
|September 19, 2024
概括
感染性内心炎由非HACEK 基因组阴性菌根 (GNB-IE) 引起的罕见但致命,影响有并发病的老年患者. 管理策略有限,在本研究中观察到的并发症和死亡率很高.
科学领域:
- 传染性疾病 传染性疾病
- 心脏病学 心脏病学
- 内部医学 内部医学
背景情况:
- 感染性内心炎是由非HACEK 基因组阴性菌根 (GNB-IE) 引起的不常见,但具有很高的发病率和死亡率.
- 由于证据有限,GNB-IE的最佳治疗和管理策略仍然定义不佳.
研究的目的:
- 描述诊断为GNB-IE的患者的临床特征和治疗方法.
- 确定与GNB-IE患者的疾病获得和不良结果相关的因素.
主要方法:
- 从2015年到2021年进行了一项回顾性,单中心描述性研究.
- 包括确定的GNB-IE的成年患者,并分析了人口统计,临床和微生物学数据.
- 特别调查了诱导因素,临床结果和一年死亡率.
主要成果:
- 确定了19名确定的GNB-IE患者,平均年龄为69岁,并具有高的并发症评分.
- 在42%的病例中,观察到鼻性获取,其中大肠杆菌和Klebsiella pneumoniae是最常见的病原体.
- 观察到的并发症率高 (74%) 和死亡率高 (21%在医院,44%在一年内).
结论:
- GNB-IE主要影响具有重大并发症和医疗保健暴露的老年人.
- 这种情况与高发病率并发症和高死亡率有关.
- 需要进一步的研究来制定GNB-IE的最佳管理准则.
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