对Valsalva在脊髓损伤中的机动反应与血管收缩能力没有广泛的关系
Kathryn Burns1,2, Adina E Draghici3,4,5, J Andrew Taylor1,2,6
1Cardiovascular Research Laboratory, Spaulding Hospital Cambridge, 1575 Cambridge Street, Cambridge, MA, 02138, USA.
概括
瓦萨尔瓦机动并不能预测脊髓损伤患者的血液动力学反应. 然而,一些患者在握手时表现出类似的血管阻力,这表明同情刺激刺激是伤害后血液动力学反应的关键.
科学领域:
- 心血管生理学心血管生理学
- 神经科学是一个神经科学.
- 康复医学 康复医学 康复医学
背景情况:
- 脊髓损伤 (SCI) 破坏了自主神经系统的控制,影响了血压调节.
- 瓦萨尔瓦机动是一种潜在的工具,用于评估SCI后的交感血管收缩功能.
- 对刺激的血液动力学反应,如倾斜和握手,对于理解SCI的自主功能至关重要.
研究的目的:
- 调查瓦萨尔瓦反应是否预测SCI患者头部向上倾斜和同度手握时的血液动力学变化.
- 为了比较SCI和健康对照个体之间的自主心血管控制.
主要方法:
- 在倾斜和握手时,与血液动力学参数 (心率,平均动脉压,腿部血流,血管阻力) 进行瓦萨尔瓦反应存在/不存在的比较.
- 研究了14名患有SCI的成年人 (C7-T12) 和14名使用重复测量ANOVA和后期测试的对照.
主要成果:
- 六名SCI患者缺乏瓦萨尔瓦反应,但这与其他血管缩反应无关.
- 在倾斜过程中,SCI组显示腿部血流量减少的趋势较小,血管阻力增加.
- 在握手期间,SCI组心率降低,血压升高,血管阻力反应减弱.
结论:
- 在SCI中,瓦萨尔瓦的反应不是在倾斜或握手时血液动力学功能的可靠预测指标.
- 一些患有SCI的个体在同度手握时表现出保留的亚损伤性血管抵抗.
- 通过特定的刺激进行交感激活可能是必要的,以引起SCI中的血液动力学反应.
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