在黑人患者的癌症中,全基因组重复率较高
Leanne M Brown1, Ryan A Hagenson1, Tilen Koklič2
1Yale University, School of Medicine, New Haven, CT, USA.
Nature communications
|September 19, 2024
概括
黑人患者在瘤中表现出更高的全基因组重复率 (WGDs),这是一个与侵袭性癌症和较差生存率相关的基因组事件. 环境暴露可能有助于这些差异.
科学领域:
- 基因组学就是基因组学.
- 癌症研究 癌症研究
- 环境健康 环境健康
背景情况:
- 在美国,黑人患癌症的死亡率不成比例地高.
- 了解不同人群中的基因组变化对于解决癌症差异至关重要.
研究的目的:
- 为了研究自报告的黑人患者癌症中的染色体复制数变化.
- 探索基因组变化,环境暴露和癌症结果中的种族差异之间的关联.
主要方法:
- 在自报黑人患者的1800多种瘤中分析染色体副本数量的变化.
- 自我报告的黑人和白人患者的瘤之间的基因组资料的比较.
- 在体外实验评估燃烧副产品对WGD诱导的影响.
- 检查与环境致癌物有关的突变特征.
主要成果:
- 自报告的黑人患者的瘤与自报告的白人患者相比,具有显著更高的全基因组重复频率 (WGD).
- 在各种癌症类型 (乳腺癌,子宫内膜癌,肺癌) 中观察到WGD的增加,与患者存活时间的减少相关.
- 自我报告的黑人患者的癌症显示出与暴露于燃烧副产品相一致的突变特征.
- 燃烧副产品被证明可以在细胞培养模型中诱导WGD.
结论:
- 全基因组重复 (WGD) 是自报告的黑人患者癌症中普遍存在的基因组变异,可能导致侵袭性疾病和较差的生存率.
- 环境暴露,如燃烧副产品,可能在诱导WGD和加剧癌症种族差异方面发挥作用.
- 这些发现突出了环境因素,特定的基因组变化和癌症结果差异之间的联系.
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