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Updated: Jun 8, 2026

Next Generation Sequencing for the Detection of Actionable Mutations in Solid and Liquid Tumors
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Published on: September 20, 2016

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蛋白质基因组特征识别EGFR和ALK的临床亚组,野生型从不吸烟的肺腺癌

Hyondeog Kim1, Wonyeop Lee2, Youngwook Kim3,4

  • 1Graduate School of Cancer Science and Policy, National Cancer Center, Goyang, Gyeonggi-do, Republic of Korea.

Experimental & molecular medicine
|September 19, 2024
PubMed
概括

这项研究揭示了在没有EGFR/ALK突变的从未吸烟者肺腺癌中四种蛋白质基因组亚型. 免疫亚型显示出最好的预后,而增殖和血管新生亚型显示出较差的结果,指导未来的肺癌疗法.

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Genetic polymorphisms in drug targets have emerged as critical determinants of interindividual variability in drug response and toxicity. Pharmacogenomic investigations increasingly focus on identifying these variations to personalize and optimize therapeutic interventions. A drug target may be a receptor, enzyme, or signaling protein involved in pharmacologic responses or disease-related pathways. While early pharmacogenetic studies focused primarily on drug metabolism, current research...
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Advances in genomics have profoundly influenced drug discovery by increasing both the speed and accuracy of pharmaceutical development. Pharmacogenomics, which examines how genetic variation influences drug response, facilitates the identification of novel therapeutic targets and enables patient stratification for personalized treatment. These strategies contribute to improved drug efficacy, minimized adverse effects, and more efficient clinical trial design.Mapping genetic differences...