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长链多不和脂肪酸补充和败血症:系统性审查和元分析
Ariadna Witte Castro1, María L Couce2,3, Carmela de Lamas2
1Research Institute of La Paz University Hospital, Madrid, Spain. ariadna.witte@idipaz.es.
Pediatric research
|September 19, 2024
概括
长链多不和脂肪酸 (LCPUFA) 补充剂没有显著降低早产婴儿的败血症发病率. 这一系统性审查没有发现确的证据,表明LCPUFA摄入量与这种脆弱人群中败血症率的降低有关.
科学领域:
- 新生儿营养新生儿营养
- 儿童传染病 儿童传染病
- 营养生物化学 营养生物化学
背景情况:
- 长链多不和脂肪酸 (LCPUFA) 对早产婴儿发育至关重要.
- 目前正在研究LCPUFA是否有潜力降低炎症和感染率,包括败血症.
- 之前对LCPUFA补充剂和早产婴儿的败血症的临床试验产生了不确定的结果.
研究的目的:
- 系统地审查和对LCPUFA补充剂和早产婴儿败血症发病率的现有数据进行元分析.
- 确定n-3多不和脂肪酸的补充是否可以降低这一群体的败血症率.
- 为儿科医生和营养学家提供全面的概述.
主要方法:
- 40项试验的系统审查和元分析.
- 在主要数据库中进行的搜索:MEDLINE,PubMed,ISI-Web of Science,EMBASE,SCOPUS,SciELO和Cochrane图书馆.
- 使用推评估,开发和评估 (GRADE) 方法对毒症发病率的数据进行分析.
主要成果:
- 35项试验提供了用于定量分析的数据.
- 服用LCPUFA补充剂并没有显著减少败血症发病率 (RR 0.95 [0.87,1.03],P=0.87).
- 在敏感性分析后,结果保持一致,没有异质性 (I2=0%).
结论:
- 补充LCPUFA与早产婴儿的败血症发病率显著降低无关.
- 目前的证据不支持使用LCPUFA仅用于本组的败血症预防.
- 可能需要进一步的研究来澄清潜在的益处或确定可能受益的特定子组.
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