尼泊尔BPKIHS接种疫苗的人群中COVID-19突破性感染,尼泊尔
Abhishek Karmacharya1, Keshav Rai2, Shraddha Siwakoti2
1Department of Microbiology, B. P. Koirala Institute of Health Sciences, Dharan, Nepal. abhikarma007@gmail.com.
BMC infectious diseases
|September 19, 2024
概括
在接种疫苗的人群中,COVID-19突破性感染是可能的,但大多数病例是轻微的. 老年患者面临更高的严重疾病和延长住院的风险,强调了疫苗接种.
科学领域:
- 传染性疾病 传染性疾病
- 疫苗学 疫苗学 疫苗学
- 公共卫生 公共卫生
背景情况:
- COVID-19疫苗显示出对严重疾病和死亡的高疗效.
- 关于尼泊尔COVID-19突破性感染的研究有限.
- 评估突破性感染特征对于公共卫生战略至关重要.
研究的目的:
- 为了确定在接种疫苗的个体中SARS-CoV-2突破性感染的流行率.
- 描述这些感染的临床特征和结果.
- 在突破性病例中识别严重疾病的风险因素.
主要方法:
- 从2022年1月到12月进行了一项描述性研究.
- 招募了200名完全接种RT-PCR疫苗并确认感染SARS-CoV-2的完全接种疫苗的人.
- 记录了人口统计数据,临床资料和结果 (严重程度,住院,死亡率).
主要成果:
- 在完全接种疫苗的人群中,突破性感染的患病率为6.2% (200/3175).
- 在突破性病例中发现了Omicron变异.
- 89%的病例轻度,9%中度,2%严重;老年患者 (>60) 住院时间较长,但没有死亡病例.
结论:
- COVID-19突破性感染可能发生在完全接种疫苗的个体中,主要有轻微的症状.
- 老年人患重症和长时间住院的风险更高.
- 疫苗接种对于减少疾病严重程度至关重要.
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