赛马动物中新兴的人类药物:分析和监管挑战
Buddhika N Dorakumbura1, Nicola M Beckett1, Elise C Cook1
1Racing Chemistry Laboratory, ChemCentre, Bentley, WA, Australia.
Drug testing and analysis
|September 19, 2024
概括
在种族动物中检测人类的治疗物质,如普雷加巴林和美特福林是具有挑战性的. 一种新的分析方法成功选了4000多个马和狗的尿液样本,确定了这些禁止物质的四个阳性病例.
科学领域:
- 分析化学 分析化学
- 法医毒理学 法医毒理学
- 兽医科学 兽医科学 兽医科学
背景情况:
- 在比赛当天的马匹和狗样本中存在人类治疗物质,如普雷加巴林和美特福林,这是一个重大问题.
- 虽然环境污染是可能的,但由于这些药物的治疗益处,不能排除故意给药.
- 普雷加巴林和甲福明在人类医学中被广泛使用,但在赛车动物中没有得到批准的用途,被认为是被禁止的物质.
研究的目的:
- 开发和验证一种敏感的分析方法,用于检测马类和犬类尿液中的普雷加巴林和美特福林.
- 在西澳大利亚12个月的时间内,调查在比赛当天的尿液样本中,普雷加巴林和美特福林的患病率.
主要方法:
- 采用了一种简单的提取技术,随后进行了针对性的超高压液体染色学轨道仪TM质谱 (UHPLC-OrbitrapTM MS).
- 该方法使用了逆相C18柱,以实现高效的分离和检测.
- 开发的方法能够同时选普雷加巴林,甲福林和150多种其他化合物.
主要成果:
- 在为期12个月的研究期间,超过4000个马和狗的尿液样本被选.
- 四个样本确实呈阳性,检测出普雷加巴林和/或甲福林的存在.
- 分析方法在识别这些具有挑战性的分子在复杂的生物矩阵中被证明是有效的.
结论:
- 开发的UHPLC-OrbitrapTM MS方法在比赛日的动物尿液样本中有效地同时查普雷加巴林和甲福林.
- 该研究在监测期间在西澳大利亚的种族动物中发现了这些禁止物质的低患病率.
- 可能需要进一步的研究来了解这些发现在马匹和狗比赛中的来源和影响.
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