Jove
Visualize
联系我们
JoVE
x logofacebook logolinkedin logoyoutube logo
关于 JoVE
概览领导团队博客JoVE 帮助中心
作者
出版流程编辑委员会范围与政策同行评审常见问题投稿
图书馆员
用户评价订阅访问资源图书馆顾问委员会常见问题
研究
JoVE JournalMethods CollectionsJoVE Encyclopedia of Experiments存档
教育
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab Manual教师资源中心教师网站
使用条款与条件
隐私政策
政策

相关概念视频

Formation of the Platelet Plug01:22

Formation of the Platelet Plug

5.2K
The platelet phase, the second stage of hemostasis, commences around 15-20 seconds after an injury. It follows and overlaps with the vascular phase, during which blood vessels constrict to minimize blood loss.
As the injured blood vessel contracts, endothelial cells undergo contraction, revealing collagen fibers in the basement membrane and underlying connective tissue. Furthermore, the plasma membrane of endothelial cells becomes adhesive, preparing the site for platelet adhesion. Platelets...
5.2K
Structure and Function of Platelets01:18

Structure and Function of Platelets

1.0K
The cell fragments known as platelets are disc-shaped, with an average diameter of about 3 μm and a thickness of roughly 1 μm. They play a crucial role in the body's vascular clotting system, which also involves plasma proteins, blood cells, and blood vessel tissues.
Platelets are continually replenished, circulating in the bloodstream for 9-12 days before being removed by phagocytes, primarily in the spleen. A microliter of circulating blood contains between 150,000 and 450,000...
1.0K

您也可能阅读

相关文章

通过共同作者、期刊和引用图与本文相关的文章。

排序
Same author

Third N-ECCO Consensus Statements on the Nursing Roles in Caring for Patients with Inflammatory Bowel Disease.

Journal of Crohn's & colitis·2026
Same author

Lung fuction impairment following cerebral ischemic stroke: Pathophysiology, mechanisms, and clinical challenges.

Respiratory physiology & neurobiology·2026
Same author

Open Book on the Water Slide: A Case Series of APC2 Pelvic Ring Injuries from High-Energy Aquatic Accidents.

Journal of clinical medicine·2026
Same author

Postpartum depression childbirth related PTSD maternal bonding sexual functioning and partner support among mothers.

Scientific reports·2026
Same author

Serum CCL18 May Reflect Multiorgan Involvement with Poor Outcome in Systemic Sclerosis.

Biomolecules·2026
Same author

Cutibacteriumacnes induces skin region-specific innate immune memory alterations in human keratinocytes.

The Journal of investigative dermatology·2025

相关实验视频

Updated: Jun 12, 2025

Microfluidics in Assessing Platelet Function
06:47

Microfluidics in Assessing Platelet Function

Published on: November 8, 2024

805

严重创伤患者血小板中的线粒体功能障碍 - 一项前性病例控制研究

Lilla Sándor1, Tibor Donka2, Bálint Baráth1

  • 1Department of Traumatology, University of Szeged, Semmelweis str 6., Szeged, 6725, Hungary.

Injury
|September 20, 2024
PubMed
概括

严重的创伤会损害血小板线粒体,减少ATP合成和凝块稳定性. 这种血小板线粒体功能障碍有助于创伤诱导的凝血病 (TIC).

关键词:
临床试验临床试验是指临床试验的临床试验.高分辨率呼吸计呼吸计线粒体功能障碍 线粒体功能障碍血小板激活是指血小板激活.创伤引起的凝血病 (TIC)

更多相关视频

LC-MS Analysis of Human Platelets as a Platform for Studying Mitochondrial Metabolism
06:04

LC-MS Analysis of Human Platelets as a Platform for Studying Mitochondrial Metabolism

Published on: April 4, 2016

11.2K
Comprehensive Analysis of Procoagulant Platelets Exhibiting Features of Necrosis, Apoptosis and Platelet Activation
04:37

Comprehensive Analysis of Procoagulant Platelets Exhibiting Features of Necrosis, Apoptosis and Platelet Activation

Published on: May 23, 2025

215

相关实验视频

Last Updated: Jun 12, 2025

Microfluidics in Assessing Platelet Function
06:47

Microfluidics in Assessing Platelet Function

Published on: November 8, 2024

805
LC-MS Analysis of Human Platelets as a Platform for Studying Mitochondrial Metabolism
06:04

LC-MS Analysis of Human Platelets as a Platform for Studying Mitochondrial Metabolism

Published on: April 4, 2016

11.2K
Comprehensive Analysis of Procoagulant Platelets Exhibiting Features of Necrosis, Apoptosis and Platelet Activation
04:37

Comprehensive Analysis of Procoagulant Platelets Exhibiting Features of Necrosis, Apoptosis and Platelet Activation

Published on: May 23, 2025

215

科学领域:

  • 线粒体生理学线粒体生理学
  • 创伤病理生理学
  • 凝血科学是一门凝血科学.

背景情况:

  • 创伤引起的凝血病 (TIC) 是严重受伤后血液凝固的复杂失衡.
  • 血小板功能对于凝块形成至关重要,与线粒体活动有关.
  • 以前的研究还没有全面调查严重创伤患者血小板中的线粒体功能障碍.

研究的目的:

  • 在患有严重创伤的患者中调查血小板线粒体功能.
  • 为了确定线粒体功能障碍和创伤引起的凝血病之间的关联.

主要方法:

  • 未来的病例控制研究涉及严重创伤患者 (ISS≥16) 和健康对照.
  • 使用Oxygraph-2k分析血小板线粒体功能,包括氧气消耗,H2O2生产和Ca2+运动.
  • 通过标准实验室测试,粘性弹性计 (ClotPro) 和聚合计 (Multiplate) 来评估凝血.

主要成果:

  • 与对照组相比,严重创伤患者的血小板线粒体氧化酸化 (OxPhos) 显著降低.
  • 在创伤患者中观察到线粒体H2O2产生增加和外线粒体Ca2+释放增加.
  • 降低凝血度 (MCF) 和延长凝血时间 (CT) 与OxPhos降低和损伤严重性评分 (ISS) 的增加相关.

结论:

  • 严重的创伤与显著的血小板线粒体功能障碍有关.
  • 这种功能障碍导致ATP合成减少和Ca2+处理受损,这对血小板激活和凝块稳定性至关重要.
  • 血小板线粒体功能障碍是创伤引起的凝血病发展的关键因素.