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α-Klotho:饮食炎症指数与加速衰老之间的隐藏联系

Ruiqiang Li¹, Baijing Zhou¹, Xueqing Deng¹

¹School of Public Health, Sun Yat-sen University, Guangzhou, People's Republic of China.

The British journal of nutrition

|September 20, 2024

概括

更高的饮食炎症指数 (DII) 与加速的生物和表型衰老有关. 长寿蛋白α-Klotho部分调解了这种关联,这表明饮食对衰老的影响的潜在途径.

科学领域:

老年学是一门学科.
营养科学营养科学
生物化学生物化学

背景情况:

新兴研究表明,较高的饮食炎症指数 (DII) 与先进的生物衰老之间存在相关性.
阿尔法-克洛托 (α-Klotho),被认为是一个与长寿相关的蛋白质,正在探索其在调解DII-衰老关系中的潜在作用.

研究的目的:

调查α-Klotho在DII与生物和表型衰老之间的关联中的作用.
评估饮食炎症如何影响衰老标志物以及α-Klotho是否是一个调解因素.

主要方法:

利用了3054名参与国家健康和营养检查调查 (NHANES) 的数据.
使用多变量线性回归来分析DII,生物年龄和表型年龄之间的关联.
进行调解分析以评估α-Klotho在DII衰老途径中的作用.

主要成果:

较高的DII与较老的生物年龄 (1.01年/DII得分增加) 和表型年龄 (1.01年/DII得分增加) 有显著的关联.
在DII和α-Klotho水平之间,以及α-Klotho与生物和表型年龄之间观察到负相关性.
阿尔法-克洛托调解了DII与生物年龄之间的10.13%,与表型年龄之间的9.61%.

结论:

升高的DII与加速的生物和表型衰老有关.
蛋白质α-Klotho部分调解了较高的DII对衰老过程的有害影响.
这些发现突出了通过α-Klotho通路将饮食模式与衰老联系起来的潜在机制.

关键词:

生物年龄生物年龄饮食炎症指数饮食炎症指数现型年龄现型年龄 α - 克洛托霍 (Klotho) 是一种

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