在患有慢性腹的患者中诊断快速结肠过渡的光学测试的额外标准
Camille Lupianez-Merly1, Saam Dilmaghani1, Kara Jencks1
1Clinical Enteric Neuroscience Translational and Epidemiological Research (C.E.N.T.E.R.), Division of Gastroenterology and Hepatology, Mayo Clinic, Rochester, Minnesota, USA.
Neurogastroenterology and motility
|September 20, 2024
概括
结肠过渡变化 (∆GC) 识别了腹患者的快速结肠过渡,即使使用正常标准测试. 这种诊断指标有助于诊断出明显增加的移动性障碍患者百分比.
科学领域:
- 胃肠病学 胃肠病学
- 医疗成像医学成像
- 诊断医学 诊断医学 诊断医学
背景情况:
- 使用标记在内的活性炭颗粒进行结肠过渡 (CT) 扫描是评估肠道运动性的标准.
- 目前的CT诊断依赖于24小时和48小时的几何中心 (GC),这表明灵敏度有限.
- 需要更敏感的方法来诊断慢性腹患者的快速CT.
研究的目的:
- 评估CT变化 (∆GC) 在患有慢性腹和正常标准CT结果 (GC24和GC48) 的患者的诊断效用.
- 将临床和研究队列中的∆GC与性别匹配的健康对照进行比较.
- 探索∆GC与其他生理标志物之间的相关性.
主要方法:
- 分析了两个患有慢性腹的成年患者队列 (701例临床,76例研究).
- ∆GC与220名健康对照的第95百分位相比较.
- 评估了∆GC和结肠空虚,便频率/一致性以及便胆酸 (BA) 度之间的相关性.
主要成果:
- 在701名正常GC24的患者中,22.3%的患者表现出基于∆GC的快速CT.
- 在研究队列中,20.6%的IBS-D和23%的BAD患者通过∆GC显示了快速CT.
- 快速的∆GC与年轻的年龄,缺乏糖尿病有关,与结肠空气和便BA水平相关.
结论:
- ∆GC在腹和正常GC24患者中发现了另外21% - 23%的快速结肠过渡患者.
- 这一指标为结肠运动障碍提供了更好的诊断灵敏度.
- ∆GC显示出作为诊断功能性胃肠道疾病的有价值工具的潜力.
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