安布洛克索尔化水喷雾剂 (Luo Runchang®) 治疗急性呼吸道传染病:一个前性,多中心,开放标签,随机对照研究
Lu Cheng1, Min Liu2, Rong Wang3
1Department of Pediatrics, Children's Hospital Affiliated to Shandong University, Jinan Children's Hospital, Jinan, Shandong, China.
Frontiers in pediatrics
|September 20, 2024
概括
安布洛克索尔化喷雾剂比口服溶液更有效地改善了患有呼吸道感染的儿童的咳症状和生活质量. 这项研究强调了喷雾剂在改善治疗坚持和治疗结果方面的潜力.
科学领域:
- 儿科 儿科 儿科
- 药理学 药理学是指药理学的学科.
- 呼吸系统医学 呼吸系统医学
背景情况:
- 咳和是儿童急性呼吸道感染的主要症状.
- 阿姆布罗克索尔是一种粘液溶解排泄剂,广泛用于呼吸道疾病.
研究的目的:
- 评估Ambroxol化喷雾与口服溶液在儿科急性呼吸道疾病中的疗效,安全性和合规性.
- 为了比较咳症状得分的改善,严重程度,生活质量和两种配方之间的坚持.
主要方法:
- 一项多中心,开放标签,随机对照研究,涉及154名儿童.
- 参与者接受了ambroxol化口服喷雾或口服溶液.
- 主要终点:咳症状得分的变化;次要终点:咳的严重程度,生活质量,坚持和不良事件.
主要成果:
- 与溶液组相比,喷雾组的咳症状总得分 (P=0.0005) 和咳严重程度得分 (P=0.012) 显著改善.
- 生活质量评分 (P<0.0001) 和药物坚持 (P<0.0001) 在喷雾配方中显著改善.
- 喷雾组 (1.33%) 与溶液组 (6.33%) 的不良事件发生率较低,尽管在统计学上并不显著.
结论:
- 与口服溶液相比,安布罗克索尔化喷雾在改善儿童咳症状和生活质量方面表现出更高的疗效.
- 喷雾配方提供了增强的粘附性和有利的安全性概况,用于治疗儿科呼吸道感染.
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