在癌症治疗中用andrographolide准信号通路 (综述)
Nur Shahirah Shaharudin1, Gurmeet Kaur Surindar Singh2,3, Teh Lay Kek2
1Department of Pharmaceutical Chemistry, Faculty of Pharmacy, Universiti Teknologi MARA, Puncak Alam, Selangor 42300, Malaysia.
Molecular and clinical oncology
|September 20, 2024
概括
安德罗格拉福利德是一种植物化合物,抑制了NF-κB和JAK/STAT等关键信号通路,对乳腺癌,结肠直肠癌和肺癌产生抗癌作用. 本综述详细介绍了这些流行癌症中的机制.
科学领域:
- 自然产品 化学 化学
- 分子生物学分子生物学
- 癌症研究 癌症研究
背景情况:
- 类是各种各样的自然化合物,具有各种各样的生物活动.
- 来自*Andrographis paniculata*的andrographolide,具有抗炎症,抗癌和抗氧化特性.
- 异常信号通路对于癌症的发展和进展至关重要.
研究的目的:
- 审查andrographolide的抗癌机制,重点关注其抑制关键信号通路.
- 阐明andrographolide在对抗乳腺癌,结肠直肠癌和肺癌中的作用.
- 通过NF-κB,HIF-1和JAK/STAT通路巩固目前关于andrographolide通过NF-κB,HIF-1和JAK/STAT通路的抗癌作用的文献.
主要方法:
- 在Google Scholar,PubMed和ScienceDirect数据库中进行文献搜索.
- 包括2010年至2023年间发表的研究.
- 专注于andrographolide在乳腺,结直肠和肺癌中的抗癌机制.
主要成果:
- 安德罗格拉福利德有效抑制多种信号通路,包括NF-κB,HIF-1,JAK/STAT,PI3K/AKT/mTOR,Wnt/β-catenin和MAPK.
- 这些抑制因素有助于andrographolide在乳腺癌,结肠直肠癌和肺癌模型中的抗癌作用.
- 特别关注NF-κB,HIF-1和JAK/STAT通路在调解这些影响中的作用.
结论:
- 安德罗格拉福利德通过向关键细胞信号通路,显示出作为抗癌剂的巨大潜力.
- 它调节NF-κB,HIF-1和JAK/STAT等途径的能力为乳腺,结直肠和肺癌提供了治疗策略.
- 对andrographolide机制的进一步研究可能会导致新的癌症治疗方法.
关键词:
在 HIF-1 路径中.在JAK/STAT路径中.通过MAPK路径.通过NF-κB路径.在PI3K/AKT/mTOR路径中.在Wnt/β-catenin路径中.安德罗格拉福利德 (andrographolide) 是一种这是一种抗癌药物.更多相关视频
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