癌症抗原153:乳腺癌患者眼球转移的危险因素
Qian-Min Ge1, Qiao-Hao Hu1, Jia-Xiang Liu1
1Department of Ophthalmology, The First Affiliated Hospital, Jiangxi Medical College, Nanchang University, Nanchang, Jiangxi 330006, P.R. China.
Experimental and therapeutic medicine
|September 20, 2024
概括
乳腺癌中的眼转移是一个不良的预后指标. 癌症抗原153 (CA153) 的升高水平是乳腺癌患者眼球转移的重要危险因素和诊断标志物.
科学领域:
- 在瘤学瘤学.
- 眼科医生 眼科 眼科
背景情况:
- 乳腺癌 (BC) 的眼转移 (OM) 与预后不佳有关.
- 识别OM的风险因素对于早期检测和管理至关重要.
研究的目的:
- 调查乳腺癌患者与没有眼转移之间的瘤标志物的差异.
- 确定乳腺癌患者眼转移的危险因素.
主要方法:
- 在629名乳腺癌患者的临床特征分析中,使用统计测试 (chi-squared,t-test,Mann-Whitney U).
- 二元物流回归和ROC曲线分析以确定OM的风险因素和诊断值.
- 对有眼转移和没有眼转移的患者进行比较.
主要成果:
- 两组之间没有年龄,性别,更年期状态或病理类型的显著差异.
- 在OM组中,状淋巴结转移的发生率显著增加.
- 癌症抗原153 (CA153) 被确定为OM的重要独立风险因素.
结论:
- CA153是乳腺癌眼转移的重要危险因素.
- 升高的CA153水平与眼球转移有关.
- 一个CA153切割值43.00U/ml显示高的诊断价值 (96.15%的灵敏度,96.02%的特异性) 的OM.
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