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相关概念视频

Bone Disorders01:29

Bone Disorders

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Aging and its effect on bone remodeling is the most common cause of bone disorders. In young and healthy people, bone deposition and resorption happen at an equal rate to maintain optimal bone health.
Bone deposition is also affected by the levels of sex hormones like estrogen and testosterone that promote osteoblast activity and bone matrix synthesis. When the level of these hormones decreases due to aging, it causes a reduction in bone deposition. As a result, bone resorption by osteoclasts...
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Functions of Thyroid Hormones01:18

Functions of Thyroid Hormones

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The thyroid hormone (TH) plays a pivotal role in the intricate orchestration of physiological processes, exerting profound effects on development, metabolism, and homeostasis throughout different life stages.
TH is indispensable for the normal development and maturation of the skeletal, muscular, and nervous systems during fetal and childhood growth. It facilitates bone mineral turnover and regulates protein synthesis in developing tissues, contributing significantly to overall growth and...
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相关实验视频

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The Creation of a Rat Model for Osteosarcopenia via Ovariectomy
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甲状腺功能障碍和皮症:一个双样本的门德尔随机化研究.

Jiaxin Wei1, Shuanglong Hou1, Peng Hei1

  • 1Department of Sport Rehabilitation, School of Graduate, Xi'an Physical Education University, Xi'an, Shaanxi, China.

Frontiers in endocrinology
|September 20, 2024
PubMed
概括

甲状腺功能障碍,包括甲状腺功能障碍和甲状腺功能障碍,增加了萨科佩尼亚的风险. 这项研究使用了门德尔的随机化来证实甲状腺疾病与肌肉质量和力量的减少之间存在因果关系.

关键词:
门德尔的随机化附的瘦肉质量 附的瘦肉量甲状腺功能过强症 甲状腺功能过强症甲状腺功能低下症 甲状腺功能低下症低手握强度的手握力.这种类型的麻症是sarcopenia.步行步伐 步行步伐 步行步伐

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科学领域:

  • 内分泌学 在内分泌学.
  • 老年病的医生 老年病的医生
  • 遗传学 遗传学 是一个

背景情况:

  • 观察性研究表明甲状腺功能障碍和肉症之间存在联系.
  • 甲状腺功能障碍和肉症之间的因果关系尚不清楚.

研究的目的:

  • 通过使用孟德尔随机化 (MR) 调查甲状腺功能障碍和肉症之间的潜在因果关系.

主要方法:

  • 利用来自全基因组关联研究 (GWAS) 甲状腺功能障碍和肉症指标 (握力,尾肌肉质量,步行节奏) 的综合数据.
  • 使用反变量加权 (IVW) 分析,加权中位数和MR-Egger作为灵敏度分析.
  • 进行异质性,性和留出一个的分析,以确保结果的稳定性.

主要成果:

  • 甲状腺功能障碍与尾肌瘦质量 (ALM) 的降低有关.
  • 甲状腺功能低下与握力和步行速度的降低有关.
  • 亚临床甲状腺功能障碍症显示与步行节奏减少有显著的关联.

结论:

  • 这项MR研究提供了证据,表明甲状腺功能障碍症,甲状腺功能障碍症和亚临床甲状腺功能障碍症在增加肉症风险方面的因果作用.
  • 甲状腺功能障碍是发展肉症的重要危险因素.