在接受高剂量登苏马布治疗的患者的牙拔牙期间,如何适当地使用抗生素?
Eiji Iwata1, Takumi Hasegawa2, Hiroaki Ohori2
1Oral and Maxillofacial Surgery, Kakogawa Central City Hospital, Kakogawa, JPN.
Cureus
|September 20, 2024
概括
对于接受德诺苏马布 (Dmab) 治疗的癌症患者进行牙拔牙,目前的抗生素实践显示出差异性. 一次手术前的阿莫西西林 (AMPC) 剂量可能足以预防与药物相关的骨缩 (MRONJ).
科学领域:
- 在瘤学瘤学.
- 在口腔外科手术.
- 药理学 药理学是指药理学的学科.
背景情况:
- 与药物相关的下巴骨硬化 (MRONJ) 是癌症患者在提取后服用德诺苏马布 (Dmab) 的风险.
- 对于这些患者的术后抗生素没有明确的指导方针.
研究的目的:
- 制定抗生素指导方针,用于牙在denosumab治疗的癌症患者.
- 调查抗生素管理与 MRONJ 发育之间的联系.
主要方法:
- 对68名接受高剂量Dmab治疗的癌症患者进行了回顾性分析,后者接受了拔牙 (2012-2022年).
- 研究了术后抗生素使用与MRONJ发病率之间的相关性.
- 统计学显著性设置为P < .05.05.
主要成果:
- 在各机构观察到抗生素类型,剂量和持续时间的显著差异.
- 阿莫西西林 (AMPC) 是最常用的抗生素.
- 在AMPC下提取的牙中,MRONJ发生在17.0%的牙中;与AMPC剂量或持续时间没有发现相关性.
结论:
- 仅仅使用外科手术期间的抗生素可能无法预防MRONJ.
- 在这个队列中,AMPC的单一手术前剂量似乎足以预防MRONJ.
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