长期COVID和超移动性谱系障碍有着共同的病理生理学
Ravindra Ganesh1, Bala Munipalli2
1Division of General Internal Medicine, Mayo Clinic, Rochester, MN, United States.
Frontiers in neurology
|September 20, 2024
概括
关节高移动性状况,如高移动性谱系障碍 (HSD) 和高移动性埃勒斯-丹洛斯综合征 (hEDS),在长期COVID (LC),ME/CFS和POTS患者中很常见. 在LC患者中,早期查高流动性对于有效的症状管理至关重要.
科学领域:
- 类风湿病学 类风湿病学
- 免疫学 免疫学 免疫学
- 神经学 神经学
背景情况:
- 超移动性谱系障碍 (HSD) 和超移动性埃勒斯-丹洛斯综合征 (hEDS) 是常见的关节超移动性疾病.
- 在HSD/hEDS症状和肌痛性脑脊髓炎/慢性疲劳综合征 (ME/CFS),纤维肌痛,姿势正静性心力衰竭综合征 (POTS) 和长期COVID (LC) 症状之间存在显著的重叠.
- 肺外表现如肌肉骨疼痛,脱机症,认知问题和疲劳在LC和HSD中都是常见的.
研究的目的:
- 为了突出关节高移动性在LC,ME/CFS,纤维肌痛和POTS等疾病中的高患病率.
- 探索巨细胞激活和持久性炎症在这些患者群体中HSD发展或恶化的潜在作用.
- 强调长期COVID患者的高流动性和相关疾病查的重要性.
主要方法:
- 审查有关关节高移动性,HSD,hEDS,ME/CFS,纤维肌痛,POTS和长期COVID的现有文献.
- 分析症状重叠和潜在的病理生理机制,包括巨细胞激活和炎症.
- 讨论诊断和治疗方面的考虑.
主要成果:
- 在30-57%的ME/CFS,纤维肌痛,POTS和LC患者中发现了关节过度运动,明显高于一般人群.
- 乳腺细胞激活和持续的炎症可能会导致结缔组织损伤和超运动的开始或恶化.
- 症状重叠表明共享的潜在病理生理学或倾向.
结论:
- 在患有长期COVID,ME/CFS,纤维肌痛或POTS的患者中,对超移动性的查至关重要.
- 治疗应以症状为重点,包括药物治疗,节奏运动,物理疗法和心身实践.
- 进一步研究关联炎症,巨细胞激活和超移动性的机制是有必要的.
关键词:
超流动的埃勒斯丹洛斯综合征超流动性谱系障碍 超流动性谱系障碍长时间的COVID.肌痛性脑筋炎/慢性疲劳综合征姿势静止性心动减速综合征 (postural orthostatic tachycardia syndrome) 是一种心动减速症候群.更多相关视频
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